Abstract
In two strains of fibroblasts originating from fragments of myocardium from a 5 day old rat of the Slonaker-Addis strain, a strain known to develop tumors but rarely, abnormal morphologic alterations took place which eventuated in neoplastic changes. This happened only after repeated exposure of the cultures to an atmosphere of nitrogen (anaerobiosis) and did not occur in the control cultures of fibroblasts originating from the same rat heart, and grown continuously throughout the same period (2 ½ years) without exposure to nitrogen.
Full Text
The Full Text of this article is available as a PDF (2.3 MB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Firor W. M., Gey G. O. Observations on the Conversion of Normal into Malignant Cells. Ann Surg. 1945 May;121(5):700–703. doi: 10.1097/00000658-194505000-00013. [DOI] [PMC free article] [PubMed] [Google Scholar]
- GREENE H. S. N. Heterologous transplantation of the Brown-Pearce tumors. Cancer Res. 1949 Dec;9(12):728-35, illust. [PubMed] [Google Scholar]
- Greene H. S., Saxton J. A. UTERINE ADENOMATA IN THE RABBIT : I. CLINICAL HISTORY, PATHOLOGY AND PRELIMINARY TRANSPLANTATION EXPERIMENTS. J Exp Med. 1938 Apr 30;67(5):691–708. doi: 10.1084/jem.67.5.691. [DOI] [PMC free article] [PubMed] [Google Scholar]
- TOOLAN H. W. Proliferation and vascularization of adult human epithelium in subcutaneous tissues of x-irradiated heterologous hosts. Proc Soc Exp Biol Med. 1951 Nov;78(2):540–543. doi: 10.3181/00379727-78-19133. [DOI] [PubMed] [Google Scholar]
- TOOLAN H. W. Successful subcutaneous growth and transplantation of human tumors in X-irradiated laboratory animals. Proc Soc Exp Biol Med. 1951 Jul;77(3):572–578. doi: 10.3181/00379727-77-18854. [DOI] [PubMed] [Google Scholar]