Abstract
Feeding of stool supernates to volunteers has demonstrated that there are at least two different types—afebrile and febrile—of acute infectious non-bacterial gastroenteritis. The afebrile illness, produced by the Marcy agent previously described, has an average incubation period of 60 hours and is characterized by watery diarrhea. The agent (FS) responsible for the febrile illness has been carried through 3 human passages. The febrile disease has an average incubation period of 27 hours and is characterized by constitutional symptoms. It is believed that the two agents are not the same because of the differences in incubation period, the clinical picture, and the absence of cross-immunity. Intranasal instillation of throat washings obtained from 2 persons with gastroenteritis failed to produce illness in 2 groups of volunteers.
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Selected References
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- BRITTEN S. A., RUBENSTEIN A. D., RASKIN N., STRASSMAN G. Epidemic diarrhea of unknown cause; report of outbreaks in three Massachusetts state hospitals. N Engl J Med. 1951 May 17;244(20):749–753. doi: 10.1056/NEJM195105172442002. [DOI] [PubMed] [Google Scholar]
- GORDON I., INGRAHAM H. S. Gastroenteritis in man due to a filtrable agent. N Y State J Med. 1949 Aug 15;49(16):1918–1920. [PubMed] [Google Scholar]
- GORDON I., MENEELY J. K., Jr, CURRIE G. D., CHICOINE A. Clinical laboratory studies in experimentally-induced epidemic nonbacterial gastroenteritis. J Lab Clin Med. 1953 Jan;41(1):133–141. [PubMed] [Google Scholar]
- Gordon I., Ingraham H. S., Korns R. F. TRANSMISSION OF EPIDEMIC GASTROENTERITIS TO HUMAN VOLUNTEERS BY ORAL ADMINISTRATION OF FECAL FILTRATES. J Exp Med. 1947 Oct 31;86(5):409–422. doi: 10.1084/jem.86.5.409. [DOI] [PMC free article] [PubMed] [Google Scholar]
- INGALLS T. H., BRITTEN S. A. Epidemic diarrhea in a school for boys. J Am Med Assoc. 1951 Jun 23;146(8):710–712. doi: 10.1001/jama.1951.03670080018005. [DOI] [PubMed] [Google Scholar]
- KUHNS D. M., WETHERBEE D. G. An epidemic of vomiting and diarrhea. U S Armed Forces Med J. 1950 Aug;1(8):861–865. [PubMed] [Google Scholar]
- SHAW E. W., MELNICK J. L., CURNEN E. C. Infection of laboratory workers with coxsackie viruses. Ann Intern Med. 1950 Jul;33(1):32–40. doi: 10.7326/0003-4819-33-1-32. [DOI] [PubMed] [Google Scholar]