Abstract
A method for the establishment and maintenance of a colony of mice free of Theiler's (TO) virus has been described. This colony has been maintained since 1947 with but one instance of contamination in 1948. Studies on the susceptibility of these mice to TO virus show that smaller doses are required to establish an infection of the intestinal tract than of the CNS. A mutant strain of TO(B) virus has been isolated which, following oral administration to mice free of TO virus, is able to cause infection of the CNS with paralysis. When fed to stock mice that carry TO virus, this TO(B) strain does not cause paralysis or other signs of CNS infection.
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Selected References
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- DEAN D. J. Mouse encephalomyelitis; immunologic studies of a non-infected colony. J Immunol. 1951 Mar;66(3):347–359. [PubMed] [Google Scholar]
- Horsfall F. L., Bauer J. H. Individual Isolation of Infected Animals in a Single Room. J Bacteriol. 1940 Oct;40(4):569–580. doi: 10.1128/jb.40.4.569-580.1940. [DOI] [PMC free article] [PubMed] [Google Scholar]
- MANDEL B. Studies on the relationship between the Theiler group of viruses and the intestinal tract of the mouse. Bull N Y Acad Med. 1951 Sep;27(9):583–585. [PMC free article] [PubMed] [Google Scholar]
- Theiler M. SPONTANEOUS ENCEPHALOMYELITIS OF MICE, A NEW VIRUS DISEASE. J Exp Med. 1937 Apr 30;65(5):705–719. doi: 10.1084/jem.65.5.705. [DOI] [PMC free article] [PubMed] [Google Scholar]
- VON MAGNUS H., VON MAGNUS P. Breeding of a colony of white mice free of encephalomyelitis virus. Acta Pathol Microbiol Scand. 1949;26(1):175–177. doi: 10.1111/j.1699-0463.1949.tb03153.x. [DOI] [PubMed] [Google Scholar]
- von MAGNUS H. Studies on mouse encephalomyelitis virus (TO strain). II. The susceptibility of ordinary albino mice compared with that of a colony of TO-free mice to TO virus inoculated by various routes. Acta Pathol Microbiol Scand. 1950;27(4):611–624. [PubMed] [Google Scholar]