Abstract
Plasma proteins of the rat have been labelled by the in vivo injection of the dye T-1824. From a study of the rate of disappearance of T-1824 from the circulating blood, and the total T-1824 content of the perfused kidney the rate of protein reabsorption from the glomerular fluid by the cells of the renal tubule has been calculated. It is concluded that protein reabsorption by the cells lining the proximal convoluted tubule of the rat kidney proceeds at a rate of at least 5 mg. per hour, equivalent to a daily filtration and reabsorption of 33 per cent of the circulating plasma protein.
Full Text
The Full Text of this article is available as a PDF (632.4 KB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Bickford R. G., Winton F. R. The influence of temperature on the isolated kidney of the dog. J Physiol. 1937 Mar 5;89(2):198–219. doi: 10.1113/jphysiol.1937.sp003473. [DOI] [PMC free article] [PubMed] [Google Scholar]
- FREINKEL N., SCHREINER G. E., ATHENS J. W. Simultaneous distribution of T-1824 and I131 labelled human serum albumin in man. J Clin Invest. 1953 Feb;32(2):138–148. doi: 10.1172/JCI102722. [DOI] [PMC free article] [PubMed] [Google Scholar]
- GILSON S. B. Studies on proteinuria in the rat. Proc Soc Exp Biol Med. 1949 Dec;72(3):608-13, illust. [PubMed] [Google Scholar]
- OLIVER J. The structure of the metabolic process in the nephron. J Mt Sinai Hosp N Y. 1948 NovâDec;15(4):175–222. [PubMed] [Google Scholar]
- RATHER L. J. Filtration, resorption, and excretion of protein by the kidney. Medicine (Baltimore) 1952 Dec;31(4):357–380. doi: 10.1097/00005792-195212000-00002. [DOI] [PubMed] [Google Scholar]
- RIGAS D. A., HELLER C. G. The amount and nature of urinary proteins in normal human subjects. J Clin Invest. 1951 Aug;30(8):853–861. doi: 10.1172/JCI102500. [DOI] [PMC free article] [PubMed] [Google Scholar]
- SCHULTZ A. L., HAMMARSTEN J. F., HELLER B. I., EBERT R. V. A critical comparison of the T-1824 dye and iodinated albumin methods for plasma volume measurement. J Clin Invest. 1953 Feb;32(2):107–112. doi: 10.1172/JCI102717. [DOI] [PMC free article] [PubMed] [Google Scholar]
- SELLERS A. L., ROBERTS S., RASK I., SMITH S., 3rd, MARMORSTON J., GOODMAN H. C. An electrophoretic study of urinary protein in the rat. J Exp Med. 1952 May 1;95(5):465–472. doi: 10.1084/jem.95.5.465. [DOI] [PMC free article] [PubMed] [Google Scholar]
- SELLERS A. L., SMITH S., 3rd, MARMORSTON J., GOODMAN H. C. Studies on the mechanism of experimental proteinuria. J Exp Med. 1952 Dec;96(6):643–652. doi: 10.1084/jem.96.6.643. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Smetana H. The Permeability of the Renal Glomeruli of Several Mammalian Species to Labelled Proteins. Am J Pathol. 1947 Mar;23(2):255–267. [PMC free article] [PubMed] [Google Scholar]