Abstract
The inhibition of multiplication of one poliomyelitis virus by a poliomyelitis virus of another immunologic type has been established by using tissue cultures of monkey testes. The degree of interference varied from none, to partial, to complete, depending upon the time between inoculation of the interfering and the challenge viruses, and the amount of each virus inoculated. Reciprocal interference was demonstrated between Types 1, 2, and 3 poliomyelitis viruses. Under conditions which resulted in complete suppression of the growth of one poliomyelitis virus by another, interference by poliomyelitis virus with the multiplication of four antigenically distinct "orphan" viruses and of three antigenically related strains of Coxsackie virus could not be demonstrated. Poliomyelitis virus rendered non-infective by formalin or by irradiation with high energy electrons or with ultraviolet light, or treated so that only traces of residual active virus remained, failed to interfere with the propagation of active homologous virus.
Full Text
The Full Text of this article is available as a PDF (1.1 MB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- BODIAN D. Differentiation of types of poliomyelitis viruses; reinfection experiments in monkeys (second attacks). Am J Hyg. 1949 Mar;49(2):200–223. doi: 10.1093/oxfordjournals.aje.a119271. [DOI] [PubMed] [Google Scholar]
- CASALS J., OLITSKY P. K., BROWN L. V. Immunization of mice with inactivated type 2 poliomyelitis virus against types 2 and 3 viruses. Proc Soc Exp Biol Med. 1952 Aug-Sep;80(4):731–736. doi: 10.3181/00379727-80-19745. [DOI] [PubMed] [Google Scholar]
- DICK G. W. A., SCHWERDT C. E., HUBER W., SHARPLESS G. R., HOWE H. A. Immunization of cotton rats with inactivated Lansing poliomyelitis virus. II. Inactivation by physical methods. Am J Hyg. 1951 Mar;53(2):131–138. doi: 10.1093/oxfordjournals.aje.a119440. [DOI] [PubMed] [Google Scholar]
- DULBECCO R., VOGT M. Plaque formation and isolation of pure lines with poliomyelitis viruses. J Exp Med. 1954 Feb;99(2):167–182. doi: 10.1084/jem.99.2.167. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Delbrück M. Interference Between Bacterial Viruses: III. The Mutual Exclusion Effect and the Depressor Effect. J Bacteriol. 1945 Aug;50(2):151–170. [PMC free article] [PubMed] [Google Scholar]
- ENDERS J. F. General preface to studies on the cultivation of poliomyelitis viruses in tissue culture. J Immunol. 1952 Dec;69(6):639–643. [PubMed] [Google Scholar]
- HENLE W. Interference phenomena between animal viruses; a review. J Immunol. 1950 Mar;64(3):203–236. [PubMed] [Google Scholar]
- LEDINKO N., MELNICK J. L. Poliomyelitis viruses in tissue culture. V. Reaction of virus and antibody; variables of the quantitative neutralization test. Am J Hyg. 1953 Sep;58(2):223–247. [PubMed] [Google Scholar]
- Lennette E. H., Koprowski H. INTERFERENCE BETWEEN VIRUSES IN TISSUE CULTURE. J Exp Med. 1946 Feb 28;83(3):195–219. [PMC free article] [PubMed] [Google Scholar]
- MELNICK J. L., AGREN K. Poliomyelitis and Coxsackie viruses isolated from normal infants in Egypt. Proc Soc Exp Biol Med. 1952 Dec;81(3):621–624. doi: 10.3181/00379727-81-19964. [DOI] [PubMed] [Google Scholar]
- MELNICK J. L., LEDINKO N. Development of neutralizing antibodies against the three types of poliomyelitis virus during an epidemic period; the ratio of inapparent infection to clinical poliomyelitis. Am J Hyg. 1953 Sep;58(2):207–222. doi: 10.1093/oxfordjournals.aje.a119602. [DOI] [PubMed] [Google Scholar]
- MELNICK J. L., RIORDAN J. T. Poliomyelitis viruses in tissue culture. IV. Protein-free nutrient media in stationary and roller tube cultures. Proc Soc Exp Biol Med. 1952 Oct;81(1):208–213. doi: 10.3181/00379727-81-19823. [DOI] [PubMed] [Google Scholar]
- MORANN G. L., MELNICK J. L. Poliomyelitis virus in tissue culture. VI. Use of kidney epithelium grown on glass. Proc Soc Exp Biol Med. 1953 Dec;84(3):558–563. doi: 10.3181/00379727-84-20710. [DOI] [PubMed] [Google Scholar]
- MORGAN J. F., MORTON H. J., PARKER R. C. Nutrition of animal cells in tissue culture; initial studies on a synthetic medium. Proc Soc Exp Biol Med. 1950 Jan;73(1):1–8. doi: 10.3181/00379727-73-17557. [DOI] [PubMed] [Google Scholar]
- Paul J. R., Trask J. D. A COMPARATIVE STUDY OF RECENTLY ISOLATED HUMAN STRAINS AND A PASSAGE STRAIN OF POLIOMYELITIS VIRUS. J Exp Med. 1933 Oct 31;58(5):513–529. doi: 10.1084/jem.58.5.513. [DOI] [PMC free article] [PubMed] [Google Scholar]
- RIORDAN J. T., LEDINKO N., MELNICK J. L. Multiplication of poliomyelitis viruses in tissue cultures of monkey testes. II. Direct isolation and typing of strains from human stools and spinal cords in roller tubes. Am J Hyg. 1952 May;55(3):339–346. doi: 10.1093/oxfordjournals.aje.a119525. [DOI] [PubMed] [Google Scholar]
- SALK J. E. Studies in human subjects on active immunization against poliomyelitis. I. A preliminary report of experiments in progress. J Am Med Assoc. 1953 Mar 28;151(13):1081–1098. [PubMed] [Google Scholar]
- WARD R., RADER D., LIPTON M. M., FREUND J. Formation of neutralizing antibody in monkeys injected with poliomyelitis virus and adjuvants. Proc Soc Exp Biol Med. 1950 Jul;74(3):536–539. doi: 10.3181/00379727-74-17964. [DOI] [PubMed] [Google Scholar]
- YOUNGNER J. S. Monolayer tissue cultures. I. Preparation and standardization of suspensions of trypsin-dispersed monkey kidney cells. Proc Soc Exp Biol Med. 1954 Feb;85(2):202–205. doi: 10.3181/00379727-85-20830. [DOI] [PubMed] [Google Scholar]
- Ziegler J. E., Horsfall F. L. INTERFERENCE BETWEEN THE INFLUENZA VIRUSES : I. THE EFFECT OF ACTIVE VIRUS UPON THE MULTIPLICATION OF INFLUENZA VIRUSES IN THE CHICK EMBRYO. J Exp Med. 1944 Apr 1;79(4):361–377. doi: 10.1084/jem.79.4.361. [DOI] [PMC free article] [PubMed] [Google Scholar]