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. 1955 Jan 1;101(1):85–108. doi: 10.1084/jem.101.1.85

IMMUNOLOGICAL RELATIONSHIPS AMONG THE MYELOMA PROTEINS

R J Slater 1, S M Ward 1, H G Kunkel 1
PMCID: PMC2136440  PMID: 13211928

Abstract

An immunological study of 21 myeloma sera was carried out to determine their relationship to components of normal γ-globulin and to each other. Ten proteins were separated for detailed characterization. Every one of the myeloma proteins studied was immunologically different, indicating individual specificity. The γ-type myeloma proteins were all related to normal γ-globulin or a fraction thereof, and although each was distinct from the others, all were related. The β-type myeloma proteins likewise were related to one another, though individually specific. Evidence was found favoring the view that some of the γ-type myeloma proteins are related to the β-type myeloma proteins although most of them were completely unrelated. Likewise the results indicated a definite but distant relationship between the β-myeloma proteins and normal γ-globulin. Certain of the β-myeloma proteins were more closely related to a fraction of normal serum of similar electrophoretic mobility. It is suggested that most multiple myeloma proteins fall into two groups or families of cross-reacting abnormal proteins, one closely related to normal γ-globulin, the other distantly related to γ-globulin with marked individual specificities.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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