Abstract
Groups of rats were fed a diet of the purified type which was supplemented by dl-ethionine to produce pancreatic damage. It was shown that animals with pancreatic damage absorbed more iron from the gastrointestinal tract than control animals without pancreatic damage. When iron was added to the diet the animals with pancreatic damage absorbed even greater quantities of iron. These findings in rats were corroborated by similar findings in mice.
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Selected References
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- ALTHAUSEN T. L., DOIG R. K., WEIDEN S., MOTTERAM R., TURNER C. N., MOORE A. Hemochromatosis; an investigation of twenty-three cases with special reference to nutrition, to iron metabolism, and to studies of hepatic and pancreatic function. Trans Assoc Am Physicians. 1950;63:209–218. [PubMed] [Google Scholar]
- ALVIZOURI M., WARREN S. Effects of DL-ethionine on the pancreas and other organs. AMA Arch Pathol. 1954 Feb;57(2):130–137. [PubMed] [Google Scholar]
- GOLDBERG R. C., CHAIKOFF I. L., DODGE A. H. Destruction of pancreatic acinar tissue by DL-ethionine. Proc Soc Exp Biol Med. 1950 Aug;74(4):869–872. doi: 10.3181/00379727-74-18073. [DOI] [PubMed] [Google Scholar]
- GOLDBERG R. C., CHAIKOFF I. L. Selective pancreatic acinar destruction by diethionine. AMA Arch Pathol. 1951 Sep;52(3):230–238. [PubMed] [Google Scholar]
- HEGSTED D. M., FINCH C. A., KINNEY T. D. The influence of diet on iron absorption; the interrelation of iron and phosphorus. J Exp Med. 1949 Aug 1;90(2):147–156. doi: 10.1084/jem.90.2.147. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hahn P. F., Bale W. F., Hettig R. A., Kamen M. D., Whipple G. H. RADIOACTIVE IRON AND ITS EXCRETION IN URINE, BILE, AND FECES. J Exp Med. 1939 Oct 31;70(5):443–451. doi: 10.1084/jem.70.5.443. [DOI] [PMC free article] [PubMed] [Google Scholar]
- KINNEY T. D., HEGSTED D. M., FINCH C. A. The influence of diet on iron absorption; the pathology of iron excess. J Exp Med. 1949 Aug 1;90(2):137–146. doi: 10.1084/jem.90.2.137. [DOI] [PMC free article] [PubMed] [Google Scholar]
- KOCH WESER D., POPPER H. Hepatic fibrosis produced by chronic ethionine feeding. Proc Soc Exp Biol Med. 1952 Jan;79(1):34–37. doi: 10.3181/00379727-79-19263. [DOI] [PubMed] [Google Scholar]
- WACHSTEIN M., MEISEL E. Cellular changes accompanying the degenerative and regenerative phase of ethionine-induced pancreatic damage in the rat. Lab Invest. 1953 Jul-Aug;2(4):253–265. [PubMed] [Google Scholar]
- WACHSTEIN M., MEISEL E. Nephrotoxic action of dl-ethionine. Proc Soc Exp Biol Med. 1951 Aug;77(4):648–651. doi: 10.3181/00379727-77-18879. [DOI] [PubMed] [Google Scholar]