Abstract
An endemiological study of enteric viruses was conducted among 136 normal children, living in households in two socio-economic groups, over a 29 month period in Charleston, West Virginia. A repeatable seasonal incidence of enteric virus excretion was noted with over 90 per cent of isolations occurring in the months of June to October. Of 592 stools examined in District I, a lower socio-economic group, 8.3 per cent yielded virus as compared to 3.1 per cent of 966 stools examined in District IV, an upper middle class district with good environmental sanitation. Among the 77 viruses isolated in tissue cultures of monkey kidneys, 44 per cent were ECHO or orphan viruses, 37 per cent Coxsackie viruses, and 19 per cent poliomyelitis viruses. Among poliovirus carriers, and 15 family contacts, 10 individuals had simultaneous heterotypic and type-specific antibody responses. The heterotypic ones were usually present at low levels and were transient in nature. Family infection with certain orphan viruses was also evident from antibody development which occurred following isolation of virus in the sentinel child.
Full Text
The Full Text of this article is available as a PDF (836.4 KB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- CONTRERAS G., BARNETT V. H., MELNICK J. L. Identification of Coxsackie viruses by immunological methods and their classification into 16 antigenically distinct types. J Immunol. 1952 Oct;69(4):395–414. [PubMed] [Google Scholar]
- DINGLE J. H., BADGER G. F., FELLER A. E., HODGES R. G., JORDAN W. S., Jr, RAMMELKAMP C. H., Jr A study of illness in a group of Cleveland families. I. Plan of study and certain general observations. Am J Hyg. 1953 Jul;58(1):16–30. doi: 10.1093/oxfordjournals.aje.a119587. [DOI] [PubMed] [Google Scholar]
- FOX J. P., GELFAND H. M., BHATT P. N., LEBLANC D. R., CONWELL D. P. Immunizing infections with poliomyelitis viruses and seroimmune patterns in Southern Louisiana. Ann N Y Acad Sci. 1955 Sep 27;61(4):968–978. doi: 10.1111/j.1749-6632.1955.tb42555.x. [DOI] [PubMed] [Google Scholar]
- MELNICK J. L. Antigenic crossings with in poliovirus types. Proc Soc Exp Biol Med. 1955 May;89(1):131–133. [PubMed] [Google Scholar]
- MELNICK J. L. Application of tissue culture methods to epidemiological studies of poliomyelitis. Am J Public Health Nations Health. 1954 May;44(5):571–580. doi: 10.2105/ajph.44.5.571. [DOI] [PMC free article] [PubMed] [Google Scholar]
- RAMOS-ALVAREZ M., SABIN A. B. Characteristics of poliomyelitis and other enteric viruses recovered in tissue culture from healthy American children. Proc Soc Exp Biol Med. 1954 Dec;87(3):655–661. doi: 10.3181/00379727-87-21474. [DOI] [PubMed] [Google Scholar]
- SALK J. E. A concept of the mechanism of immunity for preventing paralysis in poliomyelitis. Ann N Y Acad Sci. 1955 Sep 27;61(4):1023-36; discussion, 1036-8. doi: 10.1111/j.1749-6632.1955.tb42563.x. [DOI] [PubMed] [Google Scholar]
- SALK J. E., YOUNGNER J. S., WARD E. N. Use of color change of phenol red as the indicator in titrating poliomyelitis virus or its antibody in a tissue-culture system. Am J Hyg. 1954 Sep;60(2):214–230. doi: 10.1093/oxfordjournals.aje.a119714. [DOI] [PubMed] [Google Scholar]
- WALTON M., MELNICK J. L. Coxsackie virus antibody and incidence of minor illness during the summer. Public Health Rep. 1953 Dec;68(12):1167–1178. [PMC free article] [PubMed] [Google Scholar]
- WALTON M., MELNICK J. L. Poliomyelitis antibodies in two differing socioeconomic groups within the same city. Yale J Biol Med. 1955 Apr;27(5):350–370. [PMC free article] [PubMed] [Google Scholar]