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. 1956 Oct 31;104(5):707–725. doi: 10.1084/jem.104.5.707

THE PROPERDIN SYSTEM AND IMMUNITY

VI. THE INACTIVATION OF NEWCASTLE DISEASE VIRUS BY THE PROPERDIN SYSTEM

Ralph J Wedgwood 1, Harold S Ginsberg 1, Louis Pillemer 1
PMCID: PMC2136619  PMID: 13367339

Abstract

Detailed experiments are presented which indicate that the properdin system is an inhibitor of Newcastle disease virus. Viral inhibition required all known components of the properdin system: properdin, all four components of complement and magnesium; the removal of any one constituent resulted in a loss of inhibition; the replacement of the constituent restored antiviral effect. The inhibition of virus was temperature-dependent. The process of inhibition by serum resulted in a decrease in the amount of properdin available in the serum without any measurable effect on the components of complement. The prolonged incubation of inactive serum-virus mixtures with cation-exchange resin resulted in the restoration of some, but not all, of the hemagglutinating activity of the virus. The requirements of the properdin system and the implication of these findings were discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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