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. 1956 Nov 30;104(6):921–934. doi: 10.1084/jem.104.6.921

THE ENDOTOXIC PROPERTIES OF LYSATES OF GROUP A HEMOLYTIC STREPTOCOCCI

Chandler A Stetson Jr 1
PMCID: PMC2136644  PMID: 13376812

Abstract

Suspensions of group A streptococci were subjected to mechanical disruption by shaking with glass beads. The supernatant solutions produced severe delayed inflammatory reactions on intradermal injection into normal rabbits. Intravenous injections caused systemic reactions characterized by fever, leucopenia, and peripheral vasomotor phenomena. These effects were more pronounced in rabbits which had previously been infected with group A streptococci. The local and generalized Shwartzman phenomena were reproduced with these crude streptococcal lysates, and the data suggest that streptococci possess an endotoxin similar to those of Gram-negative bacterial species.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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