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. 1986 Dec;168(3):1487–1490. doi: 10.1128/jb.168.3.1487-1490.1986

Biological role of DNA methylation: sequence-specific single-strand breaks associated with hypomethylation of GATC sites in Escherichia coli DNA.

M Szyf, E Meisels, A Razin
PMCID: PMC213669  PMID: 3536887

Abstract

The effect of methylation of GATC sites in Escherichia coli DNA on the formation of single-strand breaks was studied with dam+, dam mutant, and Dam-overproducer strains. Single-strand breaks have been observed in dam mutant cells predominantly at TpT and, to a lesser extent, at CpC. In dam mutant cells harboring pTP166 (a plasmid containing the dam gene), no such nicks were observed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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