Abstract
Guinea pigs experimentally infected with mumps virus develop a delayed, hypersensitive skin reaction following the intradermal injection of heat-inactivated mumps virus. This in vivo hypersensitivity is accompanied by a state of cellular hypersensitivity which can be demonstrated in vitro by the addition of mumps viral antigen to cultures of splenic macrophages, following which they become less motile and undergo lysis. These observations support the hypothesis that the state of hypersensitivity which develops early in mumps virus infections may have a role in the pathogenesis of the disease.
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Selected References
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- BOLIN V. S., ANDERSON J. A., LEYMASTER G. R. Experimental intraocular infection of guinea pigs with mumps virus. Proc Soc Exp Biol Med. 1950 Oct;75(1):166–170. doi: 10.3181/00379727-75-18133. [DOI] [PubMed] [Google Scholar]
- BOLIN V. S., LEYMASTER G. R. Use of guinea pig eye in study of intraocular infections produced by mumps virus. Proc Soc Exp Biol Med. 1952 Jan;79(1):7–12. doi: 10.3181/00379727-79-19255. [DOI] [PubMed] [Google Scholar]
- Enders J. F., Kane L. W., Maris E. P., Stokes J. IMMUNITY IN MUMPS : V. THE CORRELATION OF THE PRESENCE OF DERMAL HYPERSENSITIVITY AND RESISTANCE TO MUMPS. J Exp Med. 1946 Sep 30;84(4):341–364. doi: 10.1084/jem.84.4.341. [DOI] [PMC free article] [PubMed] [Google Scholar]
- GANGAROSA E. J., INGLEFIELD J. T., THOMAS C. G., MORGAN H. R. Studies on hypersensitivity of human tissues in vitro. I. Tuberculin hypersensitivity. J Exp Med. 1955 Oct 1;102(4):425–433. doi: 10.1084/jem.102.4.425. [DOI] [PMC free article] [PubMed] [Google Scholar]
- HABEL K. Immunity response in mumps with complications. J Lab Clin Med. 1952 May;39(5):785–790. [PubMed] [Google Scholar]
- HANKS J. H., WALLACE R. E. Relation of oxygen and temperature in the preservation of tissues by refrigeration. Proc Soc Exp Biol Med. 1949 Jun;71(2):196–200. doi: 10.3181/00379727-71-17131. [DOI] [PubMed] [Google Scholar]
- HENLE G., DEINHARDT F., GIRARDI A. Cytolytic effects of mumps virus in tissue cultures of epithelial cells. Proc Soc Exp Biol Med. 1954 Nov;87(2):386–393. doi: 10.3181/00379727-87-21390. [DOI] [PubMed] [Google Scholar]
- KIRBER H. P., KIRBER M. W. Experimental intraocular infection with mumps virus. AMA Arch Ophthalmol. 1954 Jun;51(6):832–849. doi: 10.1001/archopht.1954.00920040842010. [DOI] [PubMed] [Google Scholar]
- MORGAN H. R., ENDERS J. F., WAGLEY P. F. A hemolysin associated with the mumps virus. J Exp Med. 1948 Nov;88(5):503–514. doi: 10.1084/jem.88.5.503. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Moen J. K., Swift H. F. TISSUE CULTURE STUDIES ON BACTERIAL HYPERSENSITIVITY : I. TUBERCULIN SENSITIVE TISSUES. J Exp Med. 1936 Aug 31;64(3):339–353. doi: 10.1084/jem.64.3.339. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Moen J. K. TISSUE CULTURE STUDIES ON BACTERIAL HYPERSENSITIVITY : III. THE PERSISTENCE IN VITRO OF THE INHERENT SENSITIVITY TO TUBERCULIN OF CELLS FROM TUBERCULOUS ANIMALS. J Exp Med. 1936 Nov 30;64(6):943–951. doi: 10.1084/jem.64.6.943. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Stokes J., Enders J. F., Maris E. P., Kane L. W. IMMUNITY IN MUMPS : VI. EXPERIMENTS ON THE VACCINATION OF HUMAN BEINGS WITH FORMOLIZED MUMPS VIRUS. J Exp Med. 1946 Oct 31;84(5):407–428. doi: 10.1084/jem.84.5.407. [DOI] [PMC free article] [PubMed] [Google Scholar]