Skip to main content
The Journal of Experimental Medicine logoLink to The Journal of Experimental Medicine
. 1957 Sep 30;106(4):477–484. doi: 10.1084/jem.106.4.477

MACROGLOBULINEMIA

II. ANTISERA SPECIFIC FOR PATHOLOGICAL MACROGLOBULINS

Leonhard Korngold 1, Gerda Van Leeuwen 1
PMCID: PMC2136806  PMID: 13475607

Abstract

Rabbits were immunized with three highly purified macroglobulins, from patients with macroglobulinemia. The antisera reacted with two macroglobulins with sedimentation constants of 19S and 26S of homologous antigen, and cross-reacted with the 7S and 19S globulins of normal γ1-globulin and the heterologous pathological 19S macroglobulins. Exhaustive absorption of these antisera with normal γ-globulins rendered them specific for the homologous macroglobulins. The antigenic properties of the pathological macroglobulins indicate that these proteins are abnormal.

Full Text

The Full Text of this article is available as a PDF (479.7 KB).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. DEUTSCH H. F., KRATOCHVIL C. H. A crystalline macroglobulin from human serum. J Biol Chem. 1956 Sep;222(1):31–37. [PubMed] [Google Scholar]
  2. DEUTSCH H. F., KRATOCHVIL C. H., MORTON J. I. Antigenic identity of hyperglobulinemic serum components with proteins of normal serum. J Biol Chem. 1956 Sep;222(1):39–51. [PubMed] [Google Scholar]
  3. HABICH H. Zur Antigenanalyse der Paraproteine bei Makroglobulinämien. Schweiz Med Wochenschr. 1953 Dec 26;83(52):1253–1256. [PubMed] [Google Scholar]
  4. KANZOW U., SCHOLTAN W., MUTING A. Serologische Differenzierung von Makroglobulinämien. Klin Wochenschr. 1955 Nov 15;33(43-44):1043–1046. doi: 10.1007/BF01467949. [DOI] [PubMed] [Google Scholar]
  5. KORNGOLD L., LIPARI R. Multiple-myeloma proteins. I. Immunological studies. Cancer. 1956 Jan-Feb;9(1):183–192. doi: 10.1002/1097-0142(195601/02)9:1<183::aid-cncr2820090119>3.0.co;2-x. [DOI] [PubMed] [Google Scholar]
  6. KORNGOLD L., LIPARI R. Multiple-myeloma proteins. III. The antigenic relationship of Bence Jones proteins to normal gammaglobulin and multiple-myeloma serum proteins. Cancer. 1956 Mar-Apr;9(2):262–272. doi: 10.1002/1097-0142(195603/04)9:2<262::aid-cncr2820090210>3.0.co;2-b. [DOI] [PubMed] [Google Scholar]
  7. KORNGOLD L., LIPARI R. Tissue antigens of human tumors grown in rats, hamsters, and eggs. Cancer Res. 1955 Mar;15(3):159–161. [PubMed] [Google Scholar]
  8. KORNGOLD L., VAN LEEUWEN G. Macroglobulinemia. I. The antigenic relationship of pathological macroglobulins to normal gamma-globulins. J Exp Med. 1957 Oct 1;106(4):467–476. doi: 10.1084/jem.106.4.467. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. KORNGOLD L., VAN LEEUWEN G. The effect of the antigen's molecular weight on the curvature of the precipitin line in the Ouchterlony technic. J Immunol. 1957 Mar;78(3):172–177. [PubMed] [Google Scholar]

Articles from The Journal of Experimental Medicine are provided here courtesy of The Rockefeller University Press

RESOURCES