Skip to main content
PMC home page
The Journal of Experimental Medicine logoLink to The Journal of Experimental Medicine
. 1957 Sep 30;106(4):467–476. doi: 10.1084/jem.106.4.467

MACROGLOBULINEMIA

I. THE ANTIGENIC RELATIONSHIP OF PATHOLOGICAL MACROGLOBULINS TO NORMALγ-GLOBULINS

Leonhard Korngold 1, Gerda Van Leeuwen 1
PMCID: PMC2136814  PMID: 13475606

Abstract

Highly purified pathological macroglobulins, which had been characterized electrophoretically and in the ultracentrifuge, were studied by the Ouchterlony gel diffusion technique. These macroglobulins were shown to be antigenically related to normal γ1-macroglobulin (19S) as well as the 7S γ-globulins. The pathological macroglobulins differ among each other and they are antigenically deficient when compared with the normal macroglobulin. There is no correlation between the macroglobulin's antigenic structure and its physico-chemical properties.

Full Text

The Full Text of this article is available as a PDF (642.8 KB).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. COHN M., DEUTSCH H. F., WETTER L. R. Biophysical studies of blood plasma proteins. XIII. Analysis of immunological heterogeneity of human gamma globulin fractions. J Immunol. 1950 May;64(5):381–395. [PubMed] [Google Scholar]
  2. DEUTSCH H. F., KRATOCHVIL C. H. A crystalline macroglobulin from human serum. J Biol Chem. 1956 Sep;222(1):31–37. [PubMed] [Google Scholar]
  3. DEUTSCH H. F., KRATOCHVIL C. H., MORTON J. I. Antigenic identity of hyperglobulinemic serum components with proteins of normal serum. J Biol Chem. 1956 Sep;222(1):39–51. [PubMed] [Google Scholar]
  4. ENGLE R. L., Jr Cryoglobulinemia, macroglobulinemia, and the aminoaciduria which is sometimes associated with multiple myeloma. J Mt Sinai Hosp N Y. 1956 Mar-Apr;23(2):193–199. [PubMed] [Google Scholar]
  5. FRANKLIN E. C., KUNKEL H. G., MULLER-EBERHARD H. J. Two types of gamma-globulin differing in carbohydrate content. Proc Soc Exp Biol Med. 1956 Oct;93(1):146–150. doi: 10.3181/00379727-93-22690. [DOI] [PubMed] [Google Scholar]
  6. HABICH H. Zur Antigenanalyse der Paraproteine bei Makroglobulinämien. Schweiz Med Wochenschr. 1953 Dec 26;83(52):1253–1256. [PubMed] [Google Scholar]
  7. JIM R. T., STEINKAMP R. C. Macroglobulinemia and its relationship to other paraproteins; with a case report. J Lab Clin Med. 1956 Apr;47(4):540–561. [PubMed] [Google Scholar]
  8. KANZOW U., SCHOLTAN W., MUTING A. Serologische Differenzierung von Makroglobulinämien. Klin Wochenschr. 1955 Nov 15;33(43-44):1043–1046. doi: 10.1007/BF01467949. [DOI] [PubMed] [Google Scholar]
  9. KORNGOLD L. Immunological cross-reactions studied by the Ouchterlony gel diffusion technique; theory and practice. J Immunol. 1956 Aug;77(2):119–122. [PubMed] [Google Scholar]
  10. KORNGOLD L., LIPARI R. Multiple-myeloma proteins. I. Immunological studies. Cancer. 1956 Jan-Feb;9(1):183–192. doi: 10.1002/1097-0142(195601/02)9:1<183::aid-cncr2820090119>3.0.co;2-x. [DOI] [PubMed] [Google Scholar]
  11. KORNGOLD L., LIPARI R. Multiple-myeloma proteins. III. The antigenic relationship of Bence Jones proteins to normal gammaglobulin and multiple-myeloma serum proteins. Cancer. 1956 Mar-Apr;9(2):262–272. doi: 10.1002/1097-0142(195603/04)9:2<262::aid-cncr2820090210>3.0.co;2-b. [DOI] [PubMed] [Google Scholar]
  12. KORNGOLD L., LIPARI R. Tissue antigens of human tumors grown in rats, hamsters, and eggs. Cancer Res. 1955 Mar;15(3):159–161. [PubMed] [Google Scholar]
  13. KORNGOLD L., VAN LEEUWEN G. Macroglobulinemia. II. Antisera specific for pathological macroglobulins. J Exp Med. 1957 Oct 1;106(4):477–484. doi: 10.1084/jem.106.4.477. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. KORNGOLD L., VAN LEEUWEN G. The effect of the antigen's molecular weight on the curvature of the precipitin line in the Ouchterlony technic. J Immunol. 1957 Mar;78(3):172–177. [PubMed] [Google Scholar]
  15. MACKAY I. R., ERIKSEN N., MOTULSKY A. G., VOLWILER W. Cryo- and macroglobulinemia; electrophoretic, ultracentrifugal and clinical studies. Am J Med. 1956 Apr;20(4):564–587. doi: 10.1016/0002-9343(56)90139-5. [DOI] [PubMed] [Google Scholar]
  16. MCFARLANE A. S., DOVEY A. An unusual case of hyperglobulinaemia. J Pathol Bacteriol. 1952 Apr;64(2):335–342. doi: 10.1002/path.1700640209. [DOI] [PubMed] [Google Scholar]
  17. MULLER-EBERHARD H. J., KUNKEL H. G. The carbohydrate of gamma-globulin and myeloma proteins. J Exp Med. 1956 Aug 1;104(2):253–269. doi: 10.1084/jem.104.2.253. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. WALDENSTROM J. Abnormal proteins in myeloma. Adv Intern Med. 1952;5:398–440. [PubMed] [Google Scholar]

Articles from The Journal of Experimental Medicine are provided here courtesy of The Rockefeller University Press

RESOURCES