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. 1958 Mar 31;107(4):507–521. doi: 10.1084/jem.107.4.507

COLOMINIC ACID, A POLYMER OF N-ACETYLNEURAMINIC ACID

Guy T Barry 1
PMCID: PMC2136837  PMID: 13513915

Abstract

All acidic carbohydrate has been isolated from the culture medium of the enteric microorganism E. coli K235 L+O. This substance has been named colominic acid. N-acetylneuraminic acid, which has been isolated from the hydrolysate of colominic acid, is believed to be the monomer unit from which colominic acid is constituted. Colominic acid is not antigenic in rabbits. Tests have failed to reveal a relationship between the ability of E. coli K235 to elaborate colominic acid and its virulence in mice.

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Selected References

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  1. Allen R. J. The estimation of phosphorus. Biochem J. 1940 Jun;34(6):858–865. doi: 10.1042/bj0340858. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. BARRY G. T., GOEBEL W. F. Colominic acid, a substance of bacterial origin related to sialic acid. Nature. 1957 Jan 26;179(4552):206–206. doi: 10.1038/179206a0. [DOI] [PubMed] [Google Scholar]
  3. BLIX F. G., GOTTSCHALK A., KLENK E. Proposed nomenclature in the field of neuraminic and sialic acids. Nature. 1957 May 25;179(4569):1088–1088. doi: 10.1038/1791088b0. [DOI] [PubMed] [Google Scholar]
  4. BLIX G., LINDBERG E., ODIN L., WERNER I. Studies on sialic acids. Acta Soc Med Ups. 1956 Jun 30;61(1-2):1–25. [PubMed] [Google Scholar]
  5. CUMMINS C. S., HARRIS H. The chemical composition of the cell wall in some gram-positive bacteria and its possible value as a taxonomic character. J Gen Microbiol. 1956 Jul;14(3):583–600. doi: 10.1099/00221287-14-3-583. [DOI] [PubMed] [Google Scholar]
  6. DISCHE Z., SHETTLES L. B., OSNOS M. New specific color reactions of hexoses and spectrophotometric micromethods for their determination. Arch Biochem. 1949 Jun;22(2):169–184. [PubMed] [Google Scholar]
  7. FREDERICQ P. Colicines et bactériophages. Ann Inst Pasteur (Paris) 1953 Jan;84(1):294–312. [PubMed] [Google Scholar]
  8. GOEBEL W. F., BARRY G. T. Colicine K. II. The preparation and properties of a substance having colicine K activity. J Exp Med. 1958 Feb 1;107(2):185–209. doi: 10.1084/jem.107.2.185. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. GOEBEL W. F., BARRY G. T., SHEDLOVSKY T. Colicine K. I. The production of colicine K in media maintained at constant pH. J Exp Med. 1956 May 1;103(5):577–588. doi: 10.1084/jem.103.5.577. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. KUNKEL H. G., TISELIUS A. Electrophoresis of proteins on filter paper. J Gen Physiol. 1951 Sep;35(1):89–118. doi: 10.1085/jgp.35.1.89. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. MOORE S., STEIN W. H. A modified ninhydrin reagent for the photometric determination of amino acids and related compounds. J Biol Chem. 1954 Dec;211(2):907–913. [PubMed] [Google Scholar]
  12. STRANGE R. E., POWELL J. F. Hexosamine-containing peptides in spores of Bacillus subtilis, B. megatherium and B. cereus. Biochem J. 1954 Sep;58(1):80–85. doi: 10.1042/bj0580080. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Tiselius A., Kabat E. A. AN ELECTROPHORETIC STUDY OF IMMUNE SERA AND PURIFIED ANTIBODY PREPARATIONS. J Exp Med. 1939 Jan 1;69(1):119–131. doi: 10.1084/jem.69.1.119. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. WERNER I., ODIN L. On the presence of sialic acid in certain glycoproteins and in gangliosides. Acta Soc Med Ups. 1952;57(3-4):230–241. [PubMed] [Google Scholar]

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