Abstract
Administration of small amounts of salmonella endotoxin (20 µg.) or of acetone-extracted BCG cells (100 µg.) increases the resistance of mice to infection with Myco. fortuitum as well as their ability to clear carbon particles from their blood stream. Whereas the increased resistance to infection persists for many weeks, the clearing power returns to a normal level within a few days. When normal mice are infected with Myco. fortuitum, there occurs during the first phase of the infectious process a rise in clearing power for carbon particles followed by a fall during the terminal phase of the disease. The rise occurs more rapidly and is more pronounced in animals previously treated with salmonella endotoxin or with killed BCG cells. This acceleration and intensification of the phagocytic response to infection can be detected even in animals which exhibit a normal phagocytic index when tested several weeks after administration of endotoxin or of BCG. Although increase in resistance to infection is correlated with activation of the so called reticulo-endothelial system, there is no evidence of any direct causal relationship between the two phenomena.
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Selected References
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- BENACERRAF B., BIOZZI G., CUENDET A., HALPERN B. N. Influence of portal blood flow and of partial hepatectomy on the granulopectic activity of the reticulo-endothelial system. J Physiol. 1955 Apr 28;128(1):1–8. doi: 10.1113/jphysiol.1955.sp005288. [DOI] [PMC free article] [PubMed] [Google Scholar]
- BENACERRAF B., SEBESTYEN M. M. Effect of bacterial endotoxins on the reticuloendothelial system. Fed Proc. 1957 Sep;16(3):860–867. [PubMed] [Google Scholar]
- BENNETT I. L., Jr, BEESON P. B. The properties and biologic effects of bacterial pyrogens. Medicine (Baltimore) 1950 Dec;29(4):365–400. doi: 10.1097/00005792-195012000-00003. [DOI] [PubMed] [Google Scholar]
- BIOZZI G., BENACERRAF B., GRUMBACH F., HALPERN B. N., LEVADITI J., RIST N. Etude de l'activité granulopexique du système réticulo-endothélial au cours de l'infection tuberculeuse expérimentale de la souris. Ann Inst Pasteur (Paris) 1954 Sep;87(3):291–300. [PubMed] [Google Scholar]
- BIOZZI G., BENACERRAF B., HALPERN B. N. The effect of Salm. typhi and its endotoxin on the phagocytic activity of the reticuloendothelial system in mice. Br J Exp Pathol. 1955 Jun;36(3):226–235. [PMC free article] [PubMed] [Google Scholar]
- BURROWS W. Endotoxins. Annu Rev Microbiol. 1951;5:181–196. doi: 10.1146/annurev.mi.05.100151.001145. [DOI] [PubMed] [Google Scholar]
- DUBOS R. J., SCHAEDLER R. W. Effects of cellular constituents of mycobacteria on the resistance of mice to heterologous infections I. Protective effects. J Exp Med. 1957 Nov 1;106(5):703–717. doi: 10.1084/jem.106.5.703. [DOI] [PMC free article] [PubMed] [Google Scholar]
- DUBOS R. J., SCHAEDLER R. W. Reversible changes in the susceptibility of mice to bacterial infections. I. Changes brought about by injection of pertussis vaccine or of bacterial endotoxins. J Exp Med. 1956 Jul 1;104(1):53–65. doi: 10.1084/jem.104.1.53. [DOI] [PMC free article] [PubMed] [Google Scholar]
- FRITZE E., DOERING P., MANECKE H., SCHOEN R. Oberflächenveränderungen der Blutzellen durch pyrogene Reizstoffe. Schweiz Med Wochenschr. 1953 Aug 22;83(34):783–786. [PubMed] [Google Scholar]
- HALPERN B. N., BIOZZI G., MENE G., BENACERRAF B. Etude quantitative de l'activité granulopexique du système réticulo-endothélial par l'injection intraveineuse d'encre de Chine chez les diverses espèces animales. I. Méthode d'étude quantitative de l'activité granulopexique du system réticuloendothélial par l'injection intraveineuse de particules de carbone de dimensions connues. Ann Inst Pasteur (Paris) 1951 Jun;80(6):582–604. [PubMed] [Google Scholar]
- HOWARD J. G., ROWLEY D., WARDLAW A. C. Stimulation of non-specific immunity by the lipid A component of bacterial lipopolysaccharide. Nature. 1957 Feb 9;179(4554):314–315. doi: 10.1038/179314a0. [DOI] [PubMed] [Google Scholar]
- KEIDERLING W., WOHLER F., WESTPHAL O. Uber bakterielle Reizstoffe. IV. Experimentelle Untersuchungen zur Differenzierung der therapeutischen Wirkungen von bakterieller Vaccine, reinem Polysaccharid-Pyrogen und acetylierten Polysaccharid-Derivaten aus gramnegativen Bakterien. Naunyn Schmiedebergs Arch Exp Pathol Pharmakol. 1953;217(3):293–311. [PubMed] [Google Scholar]
- LANDY M., PILLEMER L. Increased resistance to infection and accompanying alteration in properidin levels following administration of bacterial lipopolysaccharides. J Exp Med. 1956 Sep 1;104(3):383–409. doi: 10.1084/jem.104.3.383. [DOI] [PMC free article] [PubMed] [Google Scholar]
- ROWLEY D. Stimulation of natural immunity to Escherichia coli infection: observations on mice. Lancet. 1955 Jan 29;268(6857):232–234. doi: 10.1016/s0140-6736(55)90163-x. [DOI] [PubMed] [Google Scholar]
- THOMAS L. The physiological disturbances produced by endotoxins. Annu Rev Physiol. 1954;16:467–490. doi: 10.1146/annurev.ph.16.030154.002343. [DOI] [PubMed] [Google Scholar]
- WEISS D. W., DUBOS R. J. Antituberculous immunity induced by methanol extracts of tubercle bacilli; its enhancement by adjuvants. J Exp Med. 1956 Jan 1;103(1):73–85. doi: 10.1084/jem.103.1.73. [DOI] [PMC free article] [PubMed] [Google Scholar]