Abstract
The effect of leukopenia on the susceptibility of rabbits to the localized Shwartzman reaction was studied in those receiving whole body irradiation and nitrogen mustard respectively. Of animals receiving nitrogen mustard in which the total polymorphonuclear leukocyte count was less than 100 cells/c.mm. only 17 per cent developed positive local Shwartzman reactions whereas 75 per cent of irradiated animals with total polymorphonuclear leukocyte counts less than 100 cells/c.mm. had positive reactions. A local Shwartzman reaction occurred in 60 of 71 control rabbits (85 per cent). Animals of both the treated groups showed positive Shwartzman reactions at a time when their total polymorphonuclear leukocyte counts were less than 500 cells/c.mm. From the findings, it is concluded (a) that the presence of normal numbers of circulating polymorphonuclear leukocytes is not an obligatory prerequisite condition to the localized hemorrhagic necrosis of the Shwartzman phenomenon, and (b) the mechanisms of action of nitrogen mustard and whole body irradiation on body tissues differ in relation to the Shwartzman reaction.
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Selected References
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- BECKER R. M. Suppression of local tissue reactivity, Shwartzman phenomenon, by nitrogen mustard, benzol, and X-ray irradiation. Proc Soc Exp Biol Med. 1948 Nov;69(2):247–250. doi: 10.3181/00379727-69-16680. [DOI] [PubMed] [Google Scholar]
- GRAEF I., KARNOFSKY D. A. The clinical and pathologic effects of the nitrogen and sulfur mustards in laboratory animals. Am J Pathol. 1948 Jan;24(1):1–47. [PMC free article] [PubMed] [Google Scholar]
- STETSON C. A., GOOD R. A. Studies on the mechanism of the Shwartzman-phenomenon; evidence for the participation of polymorphonuclear leucocytes in the phenomenon. J Exp Med. 1951 Jan;93(1):49–63. doi: 10.1084/jem.93.1.49. [DOI] [PMC free article] [PubMed] [Google Scholar]
- THOMAS L., GOOD R. A. Studies on the generalized Shwartzman reaction: I. General observations concerning the phenomenon. J Exp Med. 1952 Dec;96(6):605–624. doi: 10.1084/jem.96.6.605. [DOI] [PMC free article] [PubMed] [Google Scholar]