Abstract
The "delayed hypersensitive" reactivity induced by antigen-antibody complexes has been studied from the standpoints of the role of such complexes in establishing this state, and the relationship of this state to classical delayed hypersensitivity. It has been shown that the reactivity established by antigen-antibody complexes appears early after injection, disappears within a few days, and is characterized by several properties which make it appear similar to true delayed hypersensitivity, including its appearance, its relative persistence for 48 hours, and its occurrence in the absence of antibodies. By the same tokens, it may be distinguished from hypersensitive reactions of the immediate type. It is referred to here as reactivity of the Jones-Mote type. Antigen alone stimulates exactly the same kind of early reactive state, but with larger doses of antigen this is later replaced by other immunologic responses including circulating antibodies and Arthus reactivity. If sufficiently small doses of antigen are employed, however, the "monophasic" reaction which follows antigen-antibody complexes consisting of the Jones-Mote type of skin responsiveness may be seen. The dermal reactivity under discussion is unlike classical delayed hypersensitivity chiefly in its evanescent character; it is present only during a few days early after antigen administration. It is suggested that this kind of reactivity, which may perhaps require a category of its own, may be related to the "tissue immunity" to tumor transplants which has been observed in mice.
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Selected References
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- BENACERRAF B., KABAT E. A. A quantitative study of the Arthus phenomenon induced passively in the guinea pig. J Immunol. 1950 Jan;64(1):1–19. [PubMed] [Google Scholar]
- Dienes L., Mallory T. B. Histological Studies of Hypersensitive Reactions. Am J Pathol. 1932 Nov;8(6):689–710.3. [PMC free article] [PubMed] [Google Scholar]
- KABAT E. A., BENACERRAF B. A quantitative study of passive anaphylaxis in the guinea pig; passive sensitization with non-precipitable or univalent rabbit antiovalbumin. J Immunol. 1949 May;62(1):97–101. [PubMed] [Google Scholar]
- Landsteiner K., Chase M. W. STUDIES ON THE SENSITIZATION OF ANIMALS WITH SIMPLE CHEMICAL COMPOUNDS : VII. SKIN SENSITIZATION BY INTRAPERITONEAL INJECTIONS. J Exp Med. 1940 Jan 31;71(2):237–245. doi: 10.1084/jem.71.2.237. [DOI] [PMC free article] [PubMed] [Google Scholar]
- MITCHISON N. A. Studies on the immunological response to foreign tumor transplants in the mouse. I. The role of lymph node cells in conferring immunity by adoptive transfer. J Exp Med. 1955 Aug 1;102(2):157–177. doi: 10.1084/jem.102.2.157. [DOI] [PMC free article] [PubMed] [Google Scholar]
- MTTCHISON N. A., DUBE O. L. Studies on the immunological response to foreign tumor transplants in the mouse. II. The relation between hemagglutinating antibody and graft resistance in the normal mouse and mice pretreated with tissue preparations. J Exp Med. 1955 Aug 1;102(2):179–197. doi: 10.1084/jem.102.2.179. [DOI] [PMC free article] [PubMed] [Google Scholar]
- OVARY Z., BIER O. G. Quantitative studies on passive cutaneous anaphylaxis in the guinea pig and its relationship to the Arthus phenomenon. J Immunol. 1953 Jul;71(1):6–11. [PubMed] [Google Scholar]
- OVARY Z., BRIOT M. Nouvelle méthode de dosage de l'anticorps anaphylactique et son rapport avec l'azote de l'anticorps. Ann Inst Pasteur (Paris) 1951 Dec;81(6):670–672. [PubMed] [Google Scholar]
- PAPPENHEIMER A. M., Jr, UHR J. W., YONEDA M. Delayed hypersensitivity. I. Induction of hypersensitivity to diphtheria toxin in guinea pigs by infection with Corynebacterium diphtheriae. J Exp Med. 1957 Jan 1;105(1):1–9. doi: 10.1084/jem.105.1.1. [DOI] [PMC free article] [PubMed] [Google Scholar]
- PAPPENHEIMER A. M., SALVIN S. B., UHR J. W. Delayed hypersensitivity. II. Induction of hypersensitivity in guinea pigs by means of antigen-antibody complexes. J Exp Med. 1957 Jan 1;105(1):11–24. doi: 10.1084/jem.105.1.11. [DOI] [PMC free article] [PubMed] [Google Scholar]
- RAFFEL S., ARNAUD L. E. The role of the wax of the tubercle bacillus in establishing delayed hypersensitivity, hypersensitivity to a protein antigen, egg albumin. J Exp Med. 1949 Jul;90(1):53–72. doi: 10.1084/jem.90.1.53. [DOI] [PMC free article] [PubMed] [Google Scholar]
- RAFFEL S. Chemical factors involved in the induction of infectious allergy. Experientia. 1950 Nov 15;6(11):410–419. doi: 10.1007/BF02150118. [DOI] [PubMed] [Google Scholar]
- RAFFEL S., FORNEY J. E. The role of the wax of the tubercle bacillus in establishing delayed hypersensitivity; hypersensitivity to a simple chemical substance, picryl chloride. J Exp Med. 1948 Oct 1;88(4):485–502. doi: 10.1084/jem.88.4.485. [DOI] [PMC free article] [PubMed] [Google Scholar]
- SALVIN S. B. Occurrence of delayed hypersensitivity during the development of Arthus type hypersensitivity. J Exp Med. 1958 Jan 1;107(1):109–124. doi: 10.1084/jem.107.1.109. [DOI] [PMC free article] [PubMed] [Google Scholar]
- SNELL G. D. The homograft reaction. Annu Rev Microbiol. 1957;11:439–458. doi: 10.1146/annurev.mi.11.100157.002255. [DOI] [PubMed] [Google Scholar]