Abstract
Each of several antigen-antibody systems studied has been found to affect the coagulation mechanism in the rabbit, causing a marked shortening of the coagulation time in vitro of samples of whole blood maintained in siliconized glassware. Addition of specific antigen to the blood of actively immunized animals or addition of antigen-antibody mixtures to the blood of normal animals produced the effect. The coagulation time of plasma was not affected, indicating that the phenomenon may be mediated by an effect on platelets. This effect of antigen-antibody interaction may be involved in the production of tissue damage in vivo.
Full Text
The Full Text of this article is available as a PDF (403.6 KB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- CLUFF L. E. Studies of the effect bacterial endotoxins on rabbit leucocytes. II. Development of acquired resistance. J Exp Med. 1953 Oct;98(4):349–364. doi: 10.1084/jem.98.4.349. [DOI] [PMC free article] [PubMed] [Google Scholar]
- GOOD R. A., VARCO R. L. A clinical and experimental study of agammaglobulinemia. J Lancet. 1955 Jun;75(6):245–271. [PubMed] [Google Scholar]
- GOOD R. A., ZAK S. J. Disturbances in gamma globulin synthesis as experiments of nature. Pediatrics. 1956 Jul;18(1):109–149. [PubMed] [Google Scholar]
- HEIDELBERGER M., AISENBERG A. C., HASSID W. Z. Glycogen, an immunologically specific polysaccharide. J Exp Med. 1954 Apr 1;99(4):343–353. doi: 10.1084/jem.99.4.343. [DOI] [PMC free article] [PubMed] [Google Scholar]
- McKAY D. G., SHAPIRO S. S., SHANBERGE J. N. Alterations in the blood coagulation system induced by bacterial endotoxins. II. In vitro. J Exp Med. 1958 Mar 1;107(3):369–376. doi: 10.1084/jem.107.3.369. [DOI] [PMC free article] [PubMed] [Google Scholar]
- NEILL J. M., ABRAHAMS I. Reactions of dextrans with antiserums of rabbits immunized with S. typhi. Proc Soc Exp Biol Med. 1951 Nov;78(2):537–540. doi: 10.3181/00379727-78-19132. [DOI] [PubMed] [Google Scholar]
- STETSON C. A., Jr Similarities in the mechanisms determining the Arthus and Shwartzman phenomena. J Exp Med. 1951 Oct;94(4):347–358. doi: 10.1084/jem.94.4.347. [DOI] [PMC free article] [PubMed] [Google Scholar]
- STETSON C. A., Jr Studies on the mechanism of the Shwartzman phenomenon; certain factors involved in the production of the local hemorrhagic necrosis. J Exp Med. 1951 May;93(5):489–504. doi: 10.1084/jem.93.5.489. [DOI] [PMC free article] [PubMed] [Google Scholar]
- STORCK H. Uber hämorrhagische Phänomene in der Dermatologie. Dermatologica. 1951;102(4-6):197–252. [PubMed] [Google Scholar]