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. 1959 Jan 31;109(2):127–143. doi: 10.1084/jem.109.2.127

THE BIOLOGICAL ACTIVITY OF SOLUBLE ANTIGEN-ANTIBODY COMPLEXES

II. PHYSICAL PROPERTIES OF SOLUBLE COMPLEXES HAVING SKIN-IRRITATING ACTIVITY

Kimishige Ishizaka 1, Teruko Ishizaka 1, Dan H Campbell 1
PMCID: PMC2136941  PMID: 13620844

Abstract

Soluble BSA-anti-BSA complexes, formed in antigen excess, give immediate skin reactions in normal guinea pigs. The mechanism of the reaction is not that of passive or reversed passive anaphylaxis. The complex itself is toxic. Skin activity of the complex depends on its composition. It has become obvious that the complex composed of two antigen molecules and one antibody molecule, (Ag2Ab), does not have the activity, whereas, Ag3Ab2 and more complicated complexes do. The role of complement as well as speculation on the structural changes of antibody-antigen complexes is presented.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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