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. 1959 May 1;109(5):475–485. doi: 10.1084/jem.109.5.475

THE MAMMALIAN CELL-VIRUS RELATIONSHIP

I. ATTACHMENT OF POLIOVIRUS TO CULTIVATED CELLS OF PRIMATE AND NON-PRIMATE ORIGIN

Leroy C McLaren 1, John J Holland 1, Jerome T Syverton 1
PMCID: PMC2136976  PMID: 13641571

Abstract

Primary or established strain cultures of a variety of primate cells that were susceptible to cytopathic infection strongly adsorbed poliovirus. Insusceptible non-primate cells in primary or established-strain culture did not so adsorb virus (or propagate it), with exception of the ERK-1 embryo rabbit kidney strain. All tested cells, regardless of type or susceptibility, adsorbed about 1 per cent of input virus, which became cell-associated (CAV) without loss of infectivity. In combination with susceptible or insusceptible cells, CAV was only about 90 per cent neutralized by homotypic antiserum. CAV eluted continuously from non-susceptible cells with continued incubation; eluted virus gave rise to infection and new CAV to the same degree in susceptible cells as did original virus.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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