Abstract
On hyperimmunization of rabbits with pneumococcal vaccine, increase in the content of gamma globulin and fall of albumin in the serum are produced. In such hyperimmunized rabbits, investigations of the plasma volume, albumin degradation, and the distribution of the albumin intra- and extravascularly were undertaken by Sterling's method employing rabbit albumin labelled with I131. The investigations do not suggest any significant alteration in the albumin degradation nor in the distribution between the intra- and extravascular albumin. It was demonstrated that the plasma volume increases simultaneously with increase in the gamma globulin and fall in albumin. It is concluded that the fall in serum albumin observed is due to a regulative mechanism which attempts to maintain the colloid-osmotic pressure by increasing the plasma volume.
Full Text
The Full Text of this article is available as a PDF (502.1 KB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- LAURELL C. B., LAURELL S., SKOOG N. Buffer composition in paper electrophoresis; considerations on its influence, with special reference to the interaction between small ions and proteins. Clin Chem. 1956 Apr;2(2):99–111. [PubMed] [Google Scholar]
- LOWRY O. H., ROSEBROUGH N. J., FARR A. L., RANDALL R. J. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951 Nov;193(1):265–275. [PubMed] [Google Scholar]
- OTT H. Das Blutserum bei Analbuminämie; Weitere Untersuchungen über die Serumfraktionen, das Farbstoffbindungsvermögen und den kolloidosmotischen Druck. Z Gesamte Exp Med. 1957;128(4):340–360. [PubMed] [Google Scholar]
- STERLING K. The turnover rate of serum albumin in man as measured by I131-tagged albumin. J Clin Invest. 1951 Nov;30(11):1228–1237. doi: 10.1172/JCI102542. [DOI] [PMC free article] [PubMed] [Google Scholar]
- VEALL N., PEARSON J. D., HANLEY T. The preparation of 132 I and 131 I labelled human serum albumin for clinical tracer studies. Br J Radiol. 1955 Nov;28(335):633–635. doi: 10.1259/0007-1285-28-335-633. [DOI] [PubMed] [Google Scholar]