Skip to main content
NCBI home page
The Journal of Experimental Medicine logoLink to The Journal of Experimental Medicine
. 1960 Jan 1;111(1):119–136. doi: 10.1084/jem.111.1.119

TRANSFER OF ALLERGIC ENCEPHALOMYELITIS IN RATS BY MEANS OF LYMPH NODE CELLS

Philip Y Paterson 1
PMCID: PMC2137200  PMID: 14430853

Abstract

Transfer of allergic encephalomyelitis has been accomplished by injection of lymph node cells, obtained from donor rats sensitized to spinal cord, into recipient rats pretreated neonatally with normal rat spleen cells. Transfer of the disease may be achieved most frequently when the recipients are pretreated with spleen cells of the prospective lymph node cell donors. These transfers are attributed to the use of recipients which have acquired immunological tolerance to donor lymph node cells, as a result of the spleen cell pretreatment, and in which, therefore, the donor cells can survive and function longer after transfer.

Full Text

The Full Text of this article is available as a PDF (1.4 MB).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ADLER F. L. Strain-specificity in tissue antigens of mice. J Immunol. 1955 Jan;74(1):63–70. [PubMed] [Google Scholar]
  2. ASHLEY F. L., SLOAN R. F., SCHWARTZ A. N., STEIN H., LONGMIRE W. P., Jr, SISTER GERTRUDE JOSEPH Studies on mammalian homotransplants of skin. I. Tolerance induced with a pooled antigen in rats. Plast Reconstr Surg Transplant Bull. 1958 Nov;22(5):462–470. doi: 10.1097/00006534-195811000-00006. [DOI] [PubMed] [Google Scholar]
  3. BILLINGHAM R. E., BRENT L. A simple method for inducing tolerance of skin homografts in mice. Transplant Bull. 1957 Apr;4(2):67–71. [PubMed] [Google Scholar]
  4. CANNON J. A., TERASAKI P. I., LONGMIRE W. P., Jr Unexpected manifestations of induced tolerance to skin homografts in the chicken. Ann N Y Acad Sci. 1958 Oct 7;73(3):862–868. doi: 10.1111/j.1749-6632.1959.tb40866.x. [DOI] [PubMed] [Google Scholar]
  5. EGDAHL R. H., ROLLER F. R., SWANSON R. L., VARCO R. L. Acquired tolerance to homografts and heterografts in the rat. Ann N Y Acad Sci. 1958 Oct 7;73(3):842–847. doi: 10.1111/j.1749-6632.1959.tb40864.x. [DOI] [PubMed] [Google Scholar]
  6. Eichwald E. J., Silmser C. R. Skin. Transplant Bull. 1955;2:148–149. [PubMed] [Google Scholar]
  7. HANKS J. H., WALLACE J. H. Determination of cell viability. Proc Soc Exp Biol Med. 1958 May;98(1):188–192. doi: 10.3181/00379727-98-23985. [DOI] [PubMed] [Google Scholar]
  8. HARRIS T. N., HARRIS S., FARBER M. B. Transfer of lymph node cells to recipient rabbits pre-injected with blood leucocytes of donors. Proc Soc Exp Biol Med. 1957 May;95(1):26–30. doi: 10.3181/00379727-95-23107. [DOI] [PubMed] [Google Scholar]
  9. HILL K. R. An investigation into the presence of antibodies and hypersensitivity in the encephalitis produced experimentally by the injection of homologous brain suspensions. Bull Johns Hopkins Hosp. 1949 Apr;84(4):302–333. [PubMed] [Google Scholar]
  10. HURST E. W. The pathological effects produced by sera of animals immunized with foreign nervous or splenic tissue. I. Intracisternal injection of serum. J Neurol Neurosurg Psychiatry. 1955 Aug;18(3):174–180. doi: 10.1136/jnnp.18.3.174. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. KABAT E. A., WOLF A., BEZER A. E. Studies on acute disseminated encephalomyelitis produced experimentally in rhesus monkeys. J Exp Med. 1948 Oct 1;88(4):417–426. doi: 10.1084/jem.88.4.417. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. KLUVER H., BARRERA E. A method for the combined staining of cells and fibers in the nervous system. J Neuropathol Exp Neurol. 1953 Oct;12(4):400–403. doi: 10.1097/00005072-195312040-00008. [DOI] [PubMed] [Google Scholar]
  13. Kabat E. A., Wolf A., Bezer A. E. THE RAPID PRODUCTION OF ACUTE DISSEMINATED ENCEPHALOMYELITIS IN RHESUS MONKEYS BY INJECTION OF HETEROLOGOUS AND HOMOLOGOUS BRAIN TISSUE WITH ADJUVANTS. J Exp Med. 1947 Jan 1;85(1):117–130. doi: 10.1084/jem.85.1.117. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. LIPTON M. M., FREUND J. Allergic encephalomyelitis in the rat induced by the intracutaneous injection of central nervous system tissue and adjuvants. J Immunol. 1953 Aug;71(2):98–109. [PubMed] [Google Scholar]
  15. LIPTON M. M., FREUND J. The transfer of experimental allergic encephalomyelitis in the rat by means of parabiosis. J Immunol. 1953 Nov;71(5):380–384. [PubMed] [Google Scholar]
  16. McQUARRIE D. G., KIM J. H., VARCO R. L. Long-term survival of intrastrain homografts in commercially bred rats. Transplant Bull. 1959 Jan;6(1):97–100. doi: 10.1097/00006534-195901000-00039. [DOI] [PubMed] [Google Scholar]
  17. Morgan I. M. ALLERGIC ENCEPHALOMYELITIS IN MONKEYS IN RESPONSE TO INJECTION OF NORMAL MONKEY NERVOUS TISSUE. J Exp Med. 1947 Jan 1;85(1):131–140. doi: 10.1084/jem.85.1.131. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. OLITSKY P. K., YAGER R. H. Experimental disseminated encephalomyelitis in white mice. J Exp Med. 1949 Sep;90(3):213–224. doi: 10.1084/jem.90.3.213. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. OSLER A. G., STRAUSS J. H., MAYER M. M. Diagnostic complement fixation. I. A method. Am J Syph Gonorrhea Vener Dis. 1952 Mar;36(2):140–153. [PubMed] [Google Scholar]
  20. PATERSON P. Y. Studies of immunological tolerance to nervous tissue in rats. Ann N Y Acad Sci. 1958 Oct 7;73(3):811–818. doi: 10.1111/j.1749-6632.1959.tb40860.x. [DOI] [PubMed] [Google Scholar]
  21. PREHN R. T., MAIN J. M. The influence of sex on isologous skin grafting in the mouse. J Natl Cancer Inst. 1956 Jul;17(1):35–36. [PubMed] [Google Scholar]
  22. SHORT B. F., SOBEY W. R. The effect of sex on skin grafts within inbred lines of mice. Transplant Bull. 1957 Jul;4(3):110–112. [PubMed] [Google Scholar]
  23. SNELL G. D. A cytosieve permitting sterile preparation of suspensions of tumor cells for transplantation. J Natl Cancer Inst. 1953 Jun;13(6):1511–1515. [PubMed] [Google Scholar]
  24. TERASAKI P. I., CANNON J. A., LONGMIRE W. P., Jr The specificity of tolerance to homografts in the chicken. J Immunol. 1958 Sep;81(3):246–252. [PubMed] [Google Scholar]
  25. THOMAS L., PATERSON P. Y., SMITHWICK B. Acute disseminated encephalomyelitis following immunization with homologous brain extracts; studies on the role of a circulating antibody in the production of the condition in dogs. J Exp Med. 1950 Aug;92(2):133–152. doi: 10.1084/jem.92.2.133. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. WALLACE A. L., OSLER A. G., MAYER M. M. Quantitative studies of complement fixation. V. Estimation of complement-fixing potency of immune sera and its relation to antibody-nitrogen content. J Immunol. 1950 Dec;65(6):661–673. [PubMed] [Google Scholar]
  27. WOODRUFF M. F., SIMPSON L. O. Induction of tolerance to skin homografts in rats by injection of cells from the prospective donor soon after birth. Br J Exp Pathol. 1955 Oct;36(5):494–499. [PMC free article] [PubMed] [Google Scholar]
  28. WOODRUFF M. F., SPARROW M. Further observation on the induction of tolerance of skin homografts in rats. Transplant Bull. 1957 Oct;4(4):157–159. [PubMed] [Google Scholar]

Articles from The Journal of Experimental Medicine are provided here courtesy of The Rockefeller University Press

RESOURCES