Abstract
Studies on the influence of environmental temperature on the pathogenesis of rabies in two species of experimentally infected Chiroptera, the Mexican free-tailed bat (Tadarida mexicana) and the little brown bat (Myotis lucifugus), provided evidence that little or no viral multiplication occurs in the inactive host during experimentally induced hibernation. When inoculated animals are wakened from hibernation by transfer to a warm room, virus previously in "cold storage" multiplies, reaching detectable levels in various tissues. Similar results were obtained with two strains of rabies virus, a canine rabies street virus which produced a fatal infection in man and a strain isolated from the pooled brown fat of naturally infected little brown bats. However, certain differences in the characteristics of these virus strains were observed. The canine rabies virus strain produced an encephalitic disease in mice and overt symptoms in bats; the bat rabies virus producing an encephalomyelitic disease in mice and infrequent symptoms in bats. The bat rabies virus had a greater predilection for brown adipose tissue than the canine strain. Results obtained with the bat rabies virus in hibernating animals indicate that after a period of latency in a dormant animal activated virus may reach the salivary gland more rapidly, with greater frequency, and attain higher concentrations than in animals which have not experienced a period of hibernation. The significance of these results as they relate to the natural history of bat rabies is discussed.
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- BELL J. F., MOORE G. J. Rabies virus isolated from brown fat of naturally infected bats. Proc Soc Exp Biol Med. 1960 Jan;103:140–142. doi: 10.3181/00379727-103-25438. [DOI] [PubMed] [Google Scholar]
- ENRIGHT J. B. Bats, and their relation to rabies. Annu Rev Microbiol. 1956;10:369–392. doi: 10.1146/annurev.mi.10.100156.002101. [DOI] [PubMed] [Google Scholar]
- HOGGAN M. D., ROIZMAN B., TURNER T. B. The effect of the temperature of incubation on the spread of Herpes simplex virus in an immune environment in cell culture. J Immunol. 1960 Feb;84:152–159. [PubMed] [Google Scholar]
- HOGGAN M. D., ROIZMAN B. The effect of the temperature of incubation on the formation and release of herpes simplex virus in infected FL cells. Virology. 1959 Aug;8:508–524. doi: 10.1016/0042-6822(59)90052-2. [DOI] [PubMed] [Google Scholar]
- IPSEN J., Jr The effect of environmental temperature on the immune response of mice to tetanus toxoid. J Immunol. 1952 Sep;69(3):273–283. [PubMed] [Google Scholar]
- LENNETTE E. H., SOAVE O. A., NAKAMURA K., KELLOGG G. H., Jr A fatal human case of rabies following the bite of a rabid bat (Lasionycteris noctivagans). Isolation and identification of the virus from vector and victim. J Lab Clin Med. 1960 Jan;55:89–93. [PubMed] [Google Scholar]
- LIKAR M., WILSON D. C. Observations on the interaction of poliovirus and host cells in vitro. I. The effect of environmental temperature. Br J Exp Pathol. 1958 Dec;39(6):674–678. [PMC free article] [PubMed] [Google Scholar]
- LWOFF A. Factors influencing the evolution of viral diseases at the cellular level and in the organism. Bacteriol Rev. 1959 Sep;23(3):109–124. doi: 10.1128/br.23.3.109-124.1959. [DOI] [PMC free article] [PubMed] [Google Scholar]
- SADLER W. W., ENRIGHT J. B. Effect of metabolic level of the host upon the pathogenesis of rabies in the bat. J Infect Dis. 1959 Nov-Dec;105:267–273. doi: 10.1093/infdis/105.3.267. [DOI] [PubMed] [Google Scholar]
- SULKIN S. E., ALLEN R., SIMS R. Lipotropism in pathogenesis of encephalitis viruses in insectivorous bats. Virology. 1960 May;11:302–306. doi: 10.1016/0042-6822(60)90072-6. [DOI] [PubMed] [Google Scholar]
- SULKIN S. E., KRUTZSCH P. H., ALLEN R., WALLIS C. Studies on the pathogenesis of rabies in insectivorous bats. I. Role of brown adipose tissue. J Exp Med. 1959 Sep 1;110:369–388. doi: 10.1084/jem.110.3.369. [DOI] [PMC free article] [PubMed] [Google Scholar]
- TIERKEL E. S. Recent developments in the epidemiology of rabies; introduction. Ann N Y Acad Sci. 1958 Jun 3;70(3):445–451. doi: 10.1111/j.1749-6632.1958.tb35402.x. [DOI] [PubMed] [Google Scholar]
- WALKER D. L., BORING W. D. Factors influencing host-virus interactions. III. Further studies on the alteration of Coxsackie virus infection in adult mice by environmental temperature. J Immunol. 1958 Jan;80(1):39–44. [PubMed] [Google Scholar]
- WHEELER C. E., CANBY C. M. Effect of temperature on the growth curves of herpes simplex virus in tissue cultures. J Immunol. 1959 Oct;83:392–396. [PubMed] [Google Scholar]