Abstract
The intradermal injection of aqueous solutions of certain homologous neural proteins will suppress the encephalomyelitis which is induced in guinea pigs by the previous injection of whole homologous brain with Freund's adjuvants. These neural proteins extracted by dilute acid from defatted guinea pig brain are themselves highly encephalitogenic when injected with adjuvants, but the specificity of this suppression for encephalitogenic as compared to non-encephalitogenic extracts remains to be proven. Suppression is probably not due to a non-specific stress reaction, as indicated by the absence of suppression by intradermal injections of alcohol and by statistically insignificant and inconstant effects of similar injections of tuberculin.
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Selected References
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- ALVORD E. C., Jr, KIES M. W. Clinico-pathologic correlations in experimental allergic encephalomyelitis. II. Development of an index for quantitative assay of encephalitogenic activity of antigens. J Neuropathol Exp Neurol. 1959 Jul;18(3):447–457. doi: 10.1097/00005072-195907000-00007. [DOI] [PubMed] [Google Scholar]
- CONSTANTINESCO N., HORNET T., BIRZU N., ZAVATE O., PENCEA I., RUSAN S. Rōles des bacilles tuberculeux tués dans la pathogénie de l'encéphalomyélite dite allergique, provoquée par de l'extrait cérébral additionné avec des adjuvants de freund. Ann Inst Pasteur (Paris) 1959 Jan;96(1):79–92. [PubMed] [Google Scholar]
- FERRARO A., ROIZIN L., CAZZULLO C. L. Experimental studies in allergic encephalomyelitis; prevention and production. J Neuropathol Exp Neurol. 1950 Jan;9(1):18-28, illust. doi: 10.1097/00005072-195001000-00002. [DOI] [PubMed] [Google Scholar]
- FERRARO A., ROIZIN L. Experimental allergic encephalomyelitis during and following cortone acetate treatment. J Neuropathol Exp Neurol. 1953 Oct;12(4):373–386. doi: 10.1097/00005072-195312040-00005. [DOI] [PubMed] [Google Scholar]
- GOOD R. A., CAMPBELL B., GOOD T. A. Prophylactic and therapeutic effect of para-aminobenzoic acid and sodium salicylate on experimental allergic encephalomyelitis. Proc Soc Exp Biol Med. 1949 Nov;72(2):341–347. doi: 10.3181/00379727-72-17426. [DOI] [PubMed] [Google Scholar]
- HILL K. R. An investigation into the presence of antibodies and hypersensitivity in the encephalitis produced experimentally by the injection of homologous brain suspensions. Bull Johns Hopkins Hosp. 1949 Apr;84(4):302–333. [PubMed] [Google Scholar]
- KABAT E. A., WOLF A., BEZER A. E. Studies on acute disseminated encephalomyelitis produced experimentally in rhesus monkeys. VII. The effect of cortisone. J Immunol. 1952 Mar;68(3):265–275. [PubMed] [Google Scholar]
- KIES M. W., ALVORD E. C., Jr [Prevention of allergic encephalomyelitis by prior injection of adjuvants]. Nature. 1958 Oct 18;182(4642):1106–1106. doi: 10.1038/1821106a0. [DOI] [PubMed] [Google Scholar]
- MOYER A. W., JERVIS G. A., BLACK J., KOPROWSKI H., COX H. R. Action of adrenocorticotropic hormone (ACTH) in experimental allergic encephalomyelitis of the guinea pig. Proc Soc Exp Biol Med. 1950 Nov;75(2):387–390. doi: 10.3181/00379727-75-18207. [DOI] [PubMed] [Google Scholar]
- WAKSMAN B. H. Further study of skin reactions in rabbits with experimental allergic encephalomyelitis: reactions to tests with purified white matter fractions; use of a quantitative technique for evaluating sensitivity production of sensitization and disease by intradermal injection of antigen without adjuvants. J Infect Dis. 1956 Nov-Dec;99(3):258–269. doi: 10.1093/infdis/99.3.258. [DOI] [PubMed] [Google Scholar]
- WAKSMAN B. H., MORRISON L. R. Tuberculin type sensitivity to spinal cord antigen in rabbits with isoallergic encephalomyelitis. J Immunol. 1951 Apr;66(4):421–444. [PubMed] [Google Scholar]