Abstract
Additional evidence is presented affirming the role of the intestinal pool of endotoxin in producing irreversibility in prolonged hemorrhagic shock. The fact that coliform-free rabbits tolerate exposure to a degree and duration of hemorrhagic shock which is lethal for rabbits that possess the normal flora, and that these tolerant rabbits lose their tolerance when E. coli are introduced into the gut several hours before inducing shock, demonstrate the critical importance of the size of the pool of endotoxin. That there is a proportionality between the size of the pool of endotoxin and the tolerance of hemorrhagic shock is suggested by the survival rate of several series of coliform-free rabbits fed E. coli by gavage. The rate was less the more firmly the E. coli were reestablished in the flora. The presence of the usual number of coliform bacteria in the intestinal flora does not mean the presence of the usual amount of endotoxin in these bacteria. The amount of endotoxin depends not only on the size of the population, but also, as our own experience demonstrates, on the particular ecological factors extant at any particular time which govern the amount of endotoxin elaborated by any given strain or strains of coliform bacteria.
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- FINE J., FRANK E. D., RAVIN H. A., RUTENBERG S. H., SCHWEINBURG F. B. The bacterial factor in traumatic shock. N Engl J Med. 1959 Jan 29;260(5):214–220. doi: 10.1056/NEJM195901292600505. [DOI] [PubMed] [Google Scholar]
- FINE J., RUTENBURG S., SCHWEINBURG F. B. The role of the reticulo-endothelial system in hemorrhagic shock. J Exp Med. 1959 Oct 1;110:547–569. doi: 10.1084/jem.110.4.547. [DOI] [PMC free article] [PubMed] [Google Scholar]
- FRIEDMAN E. W., SCHWEINBURG F. B., YASHAR J., FINE J. Bacterial factor in traumatic shock in the rat. Am J Physiol. 1957 Apr;189(1):197–202. doi: 10.1152/ajplegacy.1957.189.1.197. [DOI] [PubMed] [Google Scholar]
- Frank H. A., Seligman A. M., Fine J. TRAUMATIC SHOCK. X. THE TREATMENT OF HEMORRHAGIC SHOCK IRREVERSIBLE TO REPLACEMENT OF BLOOD VOLUME DEFICIENCY. J Clin Invest. 1945 Jul;24(4):435–444. doi: 10.1172/JCI101621. [DOI] [PMC free article] [PubMed] [Google Scholar]
- RAVIN H. A., ROWLEY D., JENKINS C., FINE J. On the absorption of bacterial endotoxin from the gastro-intestinal tract of the normal and shocked animal. J Exp Med. 1960 Nov 1;112:783–792. doi: 10.1084/jem.112.5.783. [DOI] [PMC free article] [PubMed] [Google Scholar]
- SCHWEINBURG F. B., SHAPIRO P. B., FRANK E. D., FINE J. Host resistance in hemorrhagic shock. IX. Demonstration of circulating lethal toxin in hemorrhagic shock. Proc Soc Exp Biol Med. 1957 Aug-Sep;95(4):646–650. doi: 10.3181/00379727-95-23316. [DOI] [PubMed] [Google Scholar]
- SHAPIRO P. B., BRONSTHER B., FRANK E. D., FINE J. Host resistance to hemorrhagic shock. XI. Role of deficient flow through intestine in development of irreversibility. Proc Soc Exp Biol Med. 1958 Feb;97(2):372–376. doi: 10.3181/00379727-97-23747. [DOI] [PubMed] [Google Scholar]
- SMIDDY F. G., FINE J. Host resistance to hemorrhagic shock. X. Induction of resistance by shock plasma and by endotoxins. Proc Soc Exp Biol Med. 1957 Nov;96(2):558–562. doi: 10.3181/00379727-96-23539. [DOI] [PubMed] [Google Scholar]
- WIZNITZER T., BETTER N., RACHLIN W., ATKINS N., FRANK E. D., FINE J. In vivo detoxification of endotoxin by the reticuloendothelial system. J Exp Med. 1960 Dec 1;112:1157–1166. doi: 10.1084/jem.112.6.1157. [DOI] [PMC free article] [PubMed] [Google Scholar]
- ZWEIFACH B. W., THOMAS L. The relationship between the vascular manifestations of shock produced by endotoxin, trauma, and hemorrhage. I. Certain similarities between the reactions in normal and endotoxin-tolerant rats. J Exp Med. 1957 Sep 1;106(3):385–401. doi: 10.1084/jem.106.3.385. [DOI] [PMC free article] [PubMed] [Google Scholar]