Abstract
Acute chloride depletion in rats is associated with the occurrence of an extensive cell damage in the mid-portion of the proximal convolutions which is followed by an excessive hyperplastic reaction of the renal epithelium; no other significant lesions were found by microdissection in either the tubules of the nephrons or the collecting system. Potassium deficiency is not essential to the development of this lesion but does increase the severity of the reaction. As in the case of potassium deficiency, chloride depletion predisposes to or exaggerates the structural alterations that accompany excess phosphate intake. The relations of the different structural changes in renal architecture that occur in various states of electrolyte imbalance are discussed as well as the relation of the lesions seen experimentally in the rat and monkey and clinically in man.
Full Text
The Full Text of this article is available as a PDF (834.9 KB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- DATTA S. P., DENT C. E., HARRIS H. An apparatus for the simultaneous production of many two-dimensional paper chromatograms. Science. 1950 Nov 24;112(2917):621–623. doi: 10.1126/science.112.2917.621. [DOI] [PubMed] [Google Scholar]
- HOLLANDER W., Jr, WINTERS R. W., WILLIAMS T. F., BRADLEY J., OLIVER J., WELT L. G. Defect in the renal tubular reabsorption of water associated with potassium depletion in rats. Am J Physiol. 1957 Jun;189(3):557–563. doi: 10.1152/ajplegacy.1957.189.3.557. [DOI] [PubMed] [Google Scholar]
- HOLLIDAY M. A. Acute metabolic alkalosis: its effect on potassium and acid excretion. J Clin Invest. 1955 Mar;34(3):428–433. doi: 10.1172/JCI103090. [DOI] [PMC free article] [PubMed] [Google Scholar]
- HOLLIDAY M. A., SEGAR W. E., BRIGHT N. H., EGAN T. The effect of potassium deficiency on the kidney. Pediatrics. 1960 Dec;26:950–959. [PubMed] [Google Scholar]
- HOLLIDAY M. A., WINTERS R. W., WELT L. G., MACDOWELL M., OLIVER J. The renal lesions of electrolyte imbalance. II. The combined effect on renal architecture of phosphate loading and potassium depletion. J Exp Med. 1959 Aug 1;110(2):161–168. doi: 10.1084/jem.110.2.161. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Mackay E. M., Oliver J. RENAL DAMAGE FOLLOWING THE INGESTION OF A DIET CONTAINING AN EXCESS OF INORGANIC PHOSPHATE. J Exp Med. 1935 Feb 28;61(3):319–334. doi: 10.1084/jem.61.3.319. [DOI] [PMC free article] [PubMed] [Google Scholar]
- RELMAN A. S., SCHWARTZ W. B. The nephropathy of potassium depletion; a clinical and pathological entity. N Engl J Med. 1956 Aug 2;255(5):195–203. doi: 10.1056/NEJM195608022550501. [DOI] [PubMed] [Google Scholar]
- SPARGO B. Kidney changes in hypokalemic alkalosis in the rat. J Lab Clin Med. 1954 May;43(5):802–814. [PubMed] [Google Scholar]