Abstract
Observations are presented on the course of experimental bacteriemia in rabbits modified by thorotrast reticuloendothelial "blockade" and mechlorethamine induced leukopenia, given singly and together. The production of severe granulocytopenia did not impair the clearance of staphylococci from the blood stream and did not enhance the impairment of clearance produced by thorotrast reticuloendothelial "blockade." Neither severe granulocytopenia nor thorotrast blockade alone produced consistent impairment in the removal of circulating E. coli from the blood stream, whereas when these conditions were present together, the early phases of clearance in these animals were virtually prevented. These results indicate that the host mechanisms operative in the control of bacteriemia differ for staphylococci and E. coli. It is suggested that the fate of bacteria within polymorphonuclear leukocytes may in part determine the importance of these cells in the removal of bacteria from the blood stream.
Full Text
The Full Text of this article is available as a PDF (643.2 KB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- BENACERRAF B., SEBESTYEN M. M., SCHLOSSMAN S. A quantitative study of the kinetics of blood clearance of P32-labelled Escherichia coli and Staphylococci by the reticuloendothelial system. J Exp Med. 1959 Jul 1;110(1):27–48. doi: 10.1084/jem.110.1.27. [DOI] [PMC free article] [PubMed] [Google Scholar]
- GREGG L. A., ROBERTSON O. H. On the nature of bacteremia in experimental pneumococcal pneumonia in the dog. II. Disappearance of pneumococci from the circulation in relation to the bactericidal action of the blood in vitro. J Exp Med. 1953 Feb 1;97(2):297–314. doi: 10.1084/jem.97.2.297. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Gilman A., Philips F. S. The Biological Actions and Therapeutic Applications of the B-Chloroethyl Amines and Sulfides. Science. 1946 Apr 5;103(2675):409–436. doi: 10.1126/science.103.2675.409. [DOI] [PubMed] [Google Scholar]
- HUNT G. A., MOSES A. J. Acute infection of mice with Smith strain of Staphylococcus aureus. Science. 1958 Dec 19;128(3338):1574–1575. doi: 10.1126/science.128.3338.1574. [DOI] [PubMed] [Google Scholar]
- MARTIN S. P., KERBY G. P., HOLLAND B. C. The effect of thorotrast on the removal of bacteria in the splanchnic area of the intact animal. J Immunol. 1952 Mar;68(3):293–296. [PubMed] [Google Scholar]
- MARTIN S. P., KERBY G. P. The splanchnic removal in rabbits during fatal bacteremias of the circulating organisms and of superimposed non-pathogenic bacteria. J Exp Med. 1950 Jul 1;92(1):45–49. doi: 10.1084/jem.92.1.45. [DOI] [PMC free article] [PubMed] [Google Scholar]
- ROGERS D. E., MELLY M. A. Further observations on the behavior of staphylococci within human leukocytes. J Exp Med. 1960 Apr 1;111:533–558. doi: 10.1084/jem.111.4.533. [DOI] [PMC free article] [PubMed] [Google Scholar]
- ROGERS D. E., MELLY M. A. Studies on bacteriemia. II. Further observations on the granulocytopenia induced by the intravenous injection of Staphylococci. J Exp Med. 1957 Feb 1;105(2):99–112. doi: 10.1084/jem.105.2.99. [DOI] [PMC free article] [PubMed] [Google Scholar]
- ROGERS D. E., MELLY M. A. Studies on bacteriemia. III. The blood stream clearance of Escherichia coli in rabbits. J Exp Med. 1957 Feb 1;105(2):113–124. doi: 10.1084/jem.105.2.113. [DOI] [PMC free article] [PubMed] [Google Scholar]
- ROGERS D. E. Studies on bacteriemia. I. Mechanisms relating to the persistence of bacteriemia in rabbits following the intravenous injection of staphylococci. J Exp Med. 1956 Jun 1;103(6):713–742. doi: 10.1084/jem.103.6.713. [DOI] [PMC free article] [PubMed] [Google Scholar]
- WARDLAW A. C., HOWARD J. G. A comparative survey of the phagocytosis of different species of bacteria by Kupffer cells; perfusion studies with the isolated rat liver. Br J Exp Pathol. 1959 Apr;40(2):113–117. [PMC free article] [PubMed] [Google Scholar]
- WOOD W. B., Jr, SMITH M. R., PERRY W. D., BERRY J. W. Studies on the cellular immunology of acute bacteremia. I. Intravascular leucocytic reaction and surface phagocytosis. J Exp Med. 1951 Dec 1;94(6):521–534. doi: 10.1084/jem.94.6.521. [DOI] [PMC free article] [PubMed] [Google Scholar]