Skip to main content
PMC home page
The Journal of Experimental Medicine logoLink to The Journal of Experimental Medicine
. 1961 Aug 1;114(2):237–256. doi: 10.1084/jem.114.2.237

THE INFLUENCE OF INFLUENZA VIRUS INFECTION ON EXOGENOUS STAPHYLOCOCCAL AND ENDOGENOUS MURINE BACTERIAL INFECTION OF THE BRONCHOPULMONARY TISSUES OF MICE

Thomas F Sellers Jr 1, Jerome Schulman 1, Claude Bouvier 1, Robert McCune 1, Edwin D Kilbourne 1
PMCID: PMC2137454  PMID: 13749920

Abstract

Mice infected with a non-mouse-adapted Asian strain of influenza A virus suffered an impaired capacity to destroy or remove staphylococci introduced by the respiratory route. This temporary inhibition of local defense mechanisms was of 7 to 10 days' duration. The persistence of staphylococci in the lung following influenza did not appear to alter the nature of the pathologic reaction to influenza virus. The presence of influenza virus infection in the respiratory tract of the mouse did not alter the fate of intravenous staphylococci in the lung or other organs. In 40 to 50 per cent of mice with influenza, purulent bronchopneumonia and infection with Pasteurella and Hemophilus of murine origin were noted. A minority of control animals evidenced such infection. The administration of antimicrobials to which the murine bacteria were susceptible prevented both the appearance of the endogenous infection with Pasteurella or Hemophilus and the purulent sequelae to influenza virus infection. The true picture of uncomplicated bronchopulmonary influenza virus infection was thus separated from the combined virus-bacteria effect otherwise encountered.

Full Text

The Full Text of this article is available as a PDF (1.2 MB).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BATTEN J. C., DINEEN P. A. P., MCCUNE R. M., Jr The effect of antimicrobial drugs on an experimental staphylococcal infection in mice. Ann N Y Acad Sci. 1956 Aug 31;65(3):91–102. doi: 10.1111/j.1749-6632.1956.tb36627.x. [DOI] [PubMed] [Google Scholar]
  2. FENNER F., MARTIN S. P., PIERCE C. H. The enumeration of viable tubercle bacilli in cultures and infected tissues. Ann N Y Acad Sci. 1949 Dec 14;52(5):751-64, illust. doi: 10.1111/j.1749-6632.1949.tb53966.x. [DOI] [PubMed] [Google Scholar]
  3. FISHER T. N., GINSBERG H. S. The reaction of influenza viruses with guinea pig polymorphonuclear leucocytes. III. Studies on the mechanism by which influenza viruses inhibit phagocytosis. Virology. 1956 Oct;2(5):656–664. doi: 10.1016/0042-6822(56)90045-9. [DOI] [PubMed] [Google Scholar]
  4. GERONE P. J., WARD T. G., CHAPPELL W. A. Combined infections in mice with influenza virus and Diplococcus pneumoniae. Am J Hyg. 1957 Nov;66(3):331–341. doi: 10.1093/oxfordjournals.aje.a119906. [DOI] [PubMed] [Google Scholar]
  5. HARFORD C. G., HAMLIN A. Effect of influenza virus on cilia and epithelial cells in the bronchi of mice. J Exp Med. 1952 Feb;95(2):173–190. doi: 10.1084/jem.95.2.173. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. HERS J. F., MASUREL N., MULDER J. Bacteriology and histopathology of the respiratory tract and lungs in fatal Asian influenza. Lancet. 1958 Nov 29;2(7057):1141–1143. doi: 10.1016/s0140-6736(58)92404-8. [DOI] [PubMed] [Google Scholar]
  7. HUNT G. A., MOSES A. J. Acute infection of mice with Smith strain of Staphylococcus aureus. Science. 1958 Dec 19;128(3338):1574–1575. doi: 10.1126/science.128.3338.1574. [DOI] [PubMed] [Google Scholar]
  8. Harford C. G., Hara M., Technical Assistance of Alice Hamlin PULMONARY EDEMA IN INFLUENZAL PNEUMONIA OF THE MOUSE AND THE RELATION OF FLUID IN THE LUNG TO THE INCEPTION OF PNEUMOCOCCAL PNEUMONIA. J Exp Med. 1950 Feb 28;91(3):245–260. doi: 10.1084/jem.91.3.245. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. LOOSLI C. G. The pathogenesis and pathology of experimental air-borne influenza virus A infections in mice. J Infect Dis. 1949 Mar–Apr;84(2):153–168. doi: 10.1093/infdis/84.2.153. [DOI] [PubMed] [Google Scholar]
  10. LOURIA D. B., BLUMENFELD H. L., ELLIS J. T., KILBOURNE E. D., ROGERS D. E. Studies on influenza in the pandemic of 1957-1958. II. Pulmonary complications of influenza. J Clin Invest. 1959 Jan;38(1 Pt 2):213–265. doi: 10.1172/JCI103791. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. MCCUNE R., DINEEN P., BATTEN J. C. The influence of antimicrobial agents on total populations of Staphylococci in animal tissues. J Immunol. 1960 Nov;85:447–464. [PubMed] [Google Scholar]
  12. MIDDLEBROOK G. An apparatus for airborne infection of mice. Proc Soc Exp Biol Med. 1952 May;80(1):105–110. doi: 10.3181/00379727-80-19538. [DOI] [PubMed] [Google Scholar]
  13. SMITH J. M., DUBOS R. J. The behavior of virulent and avirulent staphylococci in the tissues of normal mice. J Exp Med. 1956 Jan 1;103(1):87–108. doi: 10.1084/jem.103.1.87. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. VERLINDE J. D., MAKSTENIEKS O. Experimental respiratory infection in monkeys produced by influenza A virus and Staphylococcus aureus. Arch Gesamte Virusforsch. 1954 Apr 12;5(4):345–360. doi: 10.1007/BF01243004. [DOI] [PubMed] [Google Scholar]

Articles from The Journal of Experimental Medicine are provided here courtesy of The Rockefeller University Press

RESOURCES