Abstract
Acquired resistance to fully virulent strains of P. tularensis was passively transferred to normal mice by viable spleen cells or peritoneal leucocytes from donors that recovered from infection with an attenuated strain of P. tularensis. This passively transferred resistance was reflected in survival or delayed death after challenge of the recipients. The degree of passively transferred resistance was dependent upon the immune status of the donors and the number of viable immune cells transferred. There were indications that this resistance persisted only as long as the transferred tissues were compatible with the tissues of the recipient. The results support the hypothesis that immunity of mice against fully virulent strains of P. tularensis is associated with an altered state of the tissues.
Full Text
The Full Text of this article is available as a PDF (588.6 KB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- BROWNLEE K. A., HAMRE D. Studies on chemotherapy of vaccinia virus. I. An experimental design for testing antiviral agents. J Bacteriol. 1951 Feb;61(2):127–134. doi: 10.1128/jb.61.2.127-134.1951. [DOI] [PMC free article] [PubMed] [Google Scholar]
- EIGELSBACH H. T., DOWNS C. M. Prophylactic effectiveness of live and killed tularemia vaccines. I. Production of vaccine and evaluation in the white mouse and guinea pig. J Immunol. 1961 Oct;87:415–425. [PubMed] [Google Scholar]
- Foshay L., Ruchman I., Nicholes P. S. ANTITULARENSE SERUM: CORRELATION BETWEEN PROTECTIVE CAPACITY FOR WHITE RATS AND PRECIPITABLE ANTIBODY CONTENT. J Clin Invest. 1947 Jul;26(4):756–760. doi: 10.1172/JCI101858. [DOI] [PMC free article] [PubMed] [Google Scholar]
- HOLLAND J. J., PICKETT M. J. A cellular basis of immunity in experimental Brucella infection. J Exp Med. 1958 Sep 1;108(3):343–360. doi: 10.1084/jem.108.3.343. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lurie M. B., Collaboration of Peter Zappasodi STUDIES ON THE MECHANISM OF IMMUNITY IN TUBERCULOSIS : THE FATE OF TUBERCLE BACILLI INGESTED BY MONONUCLEAR PHAGOCYTES DERIVED FROM NORMAL AND IMMUNIZED ANIMALS. J Exp Med. 1942 Mar 1;75(3):247–268. doi: 10.1084/jem.75.3.247. [DOI] [PMC free article] [PubMed] [Google Scholar]
- PANNELL L., DOWNS C. M. Studies on the pathogenesis and immunity of tularemia. I. The demonstration of a protective antibody in mouse serum. J Infect Dis. 1953 Mar-Apr;92(2):195–204. doi: 10.1093/infdis/92.2.195. [DOI] [PubMed] [Google Scholar]
- POMALES-LEBRON A., STINEBRING W. R. Intracellular multiplication of Brucella abortus in normal and immune mononuclear phagocytes. Proc Soc Exp Biol Med. 1957 Jan;94(1):78–83. doi: 10.3181/00379727-94-22860. [DOI] [PubMed] [Google Scholar]
- SASLAW S., EIGELSBACH H. T., PRIOR J. A., WILSON H. E., CARHART S. Tularemia vaccine study. II. Respiratory challenge. Arch Intern Med. 1961 May;107:702–714. doi: 10.1001/archinte.1961.03620050068007. [DOI] [PubMed] [Google Scholar]
- SEVER J. L. Passive transfer of resistance to tuberculosis through use of monocytes. Proc Soc Exp Biol Med. 1960 Feb;103:326–329. doi: 10.3181/00379727-103-25506. [DOI] [PubMed] [Google Scholar]
- WON W. D. New medium for the cultivation of Pasteurella tularensis. J Bacteriol. 1958 Feb;75(2):237–239. doi: 10.1128/jb.75.2.237-239.1958. [DOI] [PMC free article] [PubMed] [Google Scholar]
- WRIGHT G. G., FEINBERG R. J. Hemagglutination by tularemia antisera: further observations on agglutination of polysaccharide-treated erythrocytes and its inhibition by polysaccharide. J Immunol. 1952 Jan;68(1):65–71. [PubMed] [Google Scholar]