Skip to main content
PMC home page
The Journal of Experimental Medicine logoLink to The Journal of Experimental Medicine
. 1962 Mar 31;115(4):731–743. doi: 10.1084/jem.115.4.731

AN ANTIGENIC BASIS FOR VIRULENCE IN STRAINS OF SALMONELLA TYPHIMURIUM

Charles R Jenkin 1
PMCID: PMC2137525  PMID: 14451585

Abstract

A study has been made of the antigenic relationships between a virulent and an avirulent strain of Salmonella typhimurium. Evidence is presented which supports the hypothesis that the susceptibility of the mouse to infection by S. typhimurium is due to an antigenic relationship between host and parasite. The antigen shared between host and parasite, appears to be absent or is masked in the avirulent strain.

Full Text

The Full Text of this article is available as a PDF (698.1 KB).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BEN-HAREL S. The phagocytic activity against Plasmodium lophurae of macrophages from ducks of varying degrees of natural resistance to this parasite. Am J Hyg. 1951 Jan;53(1):1–10. doi: 10.1093/oxfordjournals.aje.a119430. [DOI] [PubMed] [Google Scholar]
  2. BENACERRAF B., SEBESTYEN M. M., SCHLOSSMAN S. A quantitative study of the kinetics of blood clearance of P32-labelled Escherichia coli and Staphylococci by the reticuloendothelial system. J Exp Med. 1959 Jul 1;110(1):27–48. doi: 10.1084/jem.110.1.27. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. BIOZZI G., BENACERRAF B., HALPERN B. N. Quantitative study of the granulopectic activity of the reticulo-endothelial system. II. A study of the kinetics of the R. E. S. in relation to the dose of carbon injected; relationship between the weight of the organs and their activity. Br J Exp Pathol. 1953 Aug;34(4):441–457. [PMC free article] [PubMed] [Google Scholar]
  4. COHN Z. A., MORSE S. I. Interactions between rabbit polymorphonuclear leucocytes and staphylococci. J Exp Med. 1959 Sep 1;110:419–443. doi: 10.1084/jem.110.3.419. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. CRUMPTON M. J., DAVIES D. A., HUTCHISON A. M. The serological specificities of Pasteurella pseudotuberculosis somatic antigens. J Gen Microbiol. 1958 Feb;18(1):129–139. doi: 10.1099/00221287-18-1-129. [DOI] [PubMed] [Google Scholar]
  6. DAVIES D. A., CRUMPTON M. J., MACPHERSON I. A., HUTCHISON A. M. The adsorption of bacterial polysaccharides by erythrocytes. Immunology. 1958 Apr;1(2):157–171. [PMC free article] [PubMed] [Google Scholar]
  7. DAVIES D. A., STAUB A. M., FROMME I., LUDERITZ O., WESTPHAL O. Contribution of deoxymethylpentoses to the serological specificity of some bacterial polysaccharides, and the recognition of a new sugar, paratose. Nature. 1958 Mar 22;181(4612):822–823. doi: 10.1038/181822a0. [DOI] [PubMed] [Google Scholar]
  8. HIRSCH J. G., CHURCH A. B. Studies of phagocytosis of group A streptococci by polymorphonuclear leucocytes in vitro. J Exp Med. 1960 Mar 1;111:309–322. doi: 10.1084/jem.111.3.309. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. HOWARD J. G., ROWLEY D., WARDLAW A. C. Investigations on the mechanism of stimulation of non-specific immunity by bacterial lipopolysaccharides. Immunology. 1958 Jul;1(3):181–203. [PMC free article] [PubMed] [Google Scholar]
  10. JENKIN C. R., ROWLEY D. Opsonins as determinants of survival in intraperitoneal infections of mice. Nature. 1959 Aug 8;184(Suppl 7):474–475. doi: 10.1038/184474a0. [DOI] [PubMed] [Google Scholar]
  11. JENKIN C. R., ROWLEY D. The role of opsonins in the clearance of living and inert particles by cells of the reticuloendothelial system. J Exp Med. 1961 Sep 1;114:363–374. doi: 10.1084/jem.114.3.363. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. JENKIN C. R., ROWLEY D. Toxic proteins from Vibrio cholerae and water vibrios which are lethal for mice. J Gen Microbiol. 1959 Aug;21:191–202. doi: 10.1099/00221287-21-1-191. [DOI] [PubMed] [Google Scholar]
  13. JENKIN C., BENACERRAF B. In vitro studies on the interaction between mouse peritoneal macrophages and strains of Salmonella and Escherichia coli. J Exp Med. 1960 Aug 1;112:403–417. doi: 10.1084/jem.112.2.403. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Jerne N. K. THE NATURAL-SELECTION THEORY OF ANTIBODY FORMATION. Proc Natl Acad Sci U S A. 1955 Nov 15;41(11):849–857. doi: 10.1073/pnas.41.11.849. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. MACKANESS G. B. The phagocytosis and inactivation of staphylococci by macrophages of normal rabbits. J Exp Med. 1960 Jul 1;112:35–53. doi: 10.1084/jem.112.1.35. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. MICHAEL J. G., WHITBY J. L., LANDY M. Increase in specific bactericidal antibodies after administration of endotoxin. Nature. 1961 Jul 15;191:296–297. doi: 10.1038/191296a0. [DOI] [PubMed] [Google Scholar]
  17. MUSCHEL L. H. Bactericidal activity of normal serum against bacterial cultures. II. Activity against Eschericha coli strains. Proc Soc Exp Biol Med. 1960 Mar;103:632–636. doi: 10.3181/00379727-103-25619. [DOI] [PubMed] [Google Scholar]
  18. MUSCHEL L. H., CHAMBERLIN R. H., OSAWA E. Bactericidal activity of normal serum against bacterial cultures. I. Activity against Salmonella typhi strains. Proc Soc Exp Biol Med. 1958 Feb;97(2):376–382. doi: 10.3181/00379727-97-23748. [DOI] [PubMed] [Google Scholar]
  19. ROBERTSON O. H., HAMBURGER M., Jr, GREGG L. A. On the nature of bacteremia in experimental pneumococcal pneumonia in the dog. I. Relationship of natural pneumococcidal-promoting activity of the serum to blood invasion. J Exp Med. 1953 Feb 1;97(2):283–296. doi: 10.1084/jem.97.2.283. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. ROWLEY D. The role of opsonins in non-specific immunity. J Exp Med. 1960 Jan 1;111:137–144. doi: 10.1084/jem.111.1.137. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. ROWLEY D., WHITBY J. L. The bactericidal activity of mouse macrophages in vitro. Br J Exp Pathol. 1959 Oct;40:507–515. [PMC free article] [PubMed] [Google Scholar]
  22. STAUB A. M., TINELLI R., LUDERITZ O., WESTPHAL O. Etude immunochimique sur les Salmonella. V. Rôle de quelques sucres, et en particulier des 3-6 didésoxyhexoses, dans la spécificité des antigènes O du tableau de Kauffmann-White. Ann Inst Pasteur (Paris) 1959 Mar;96(3):303–332. [PubMed] [Google Scholar]
  23. Springer G. F., Williamson P., Brandes W. C. BLOOD GROUP ACTIVITY OF GRAM-NEGATIVE BACTERIA. J Exp Med. 1961 Jun 1;113(6):1077–1093. doi: 10.1084/jem.113.6.1077. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. WHITBY J. L., ROWLEY D. The role of macrophages in the elimination of bacteria from the mouse peritoneum. Br J Exp Pathol. 1959 Aug;40:358–370. [PMC free article] [PubMed] [Google Scholar]

Articles from The Journal of Experimental Medicine are provided here courtesy of The Rockefeller University Press

RESOURCES