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. 1962 Sep 1;116(3):347–364. doi: 10.1084/jem.116.3.347

THE ROLE OF ANTIBODY, DELAYED HYPERSENSITIVITY, AND INTERFERON PRODUCTION IN RECOVERY OF GUINEA PIGS FROM PRIMARY INFECTION WITH VACCINIA VIRUS

Robert M Friedman 1, Samuel Baron 1, Charles E Buckler 1, Robert I Steinmuller 1
PMCID: PMC2137548  PMID: 13895287

Abstract

In guinea pigs, methotrexate and x-radiation have been employed to block the development of delayed hypersensitivity and of antibody to vaccinia virus during experimental infection. Animals whose specific responses were blocked by x-radiation and methotrexate recovered from vaccinia virus infection as rapidly as non-treated control animals suggesting that these responses were not essential in recovery of the infected animals. A virus-inhibiting substance with the properties of interferon was present in skin of untreated and methotrexate- and x-radiation-treated animals infected with vaccinia virus.

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Selected References

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