Abstract
Antitoxic and antibacterial immunity have been clearly differentiated in the experimental mouse infection produced by the diffuse colonial variant of the Smith strain of Staphylococcus aureus. Immunization with crude toxoid protected mice from otherwise lethal doses of alpha hemolysin, but did not alter mortality following intraperitoneal infection with living staphylococci. Conversely, animals immunized with heat killed vaccines were readily killed by culture supernates containing alpha hemolysin, but were strikingly protected from otherwise fatal intraperitoneal infection with viable staphylococci. Protection was directly related to the ability of the immunizing substance to promote early intraperitoneal phagocytosis of the infecting inoculum. In these studies with the Smith diffuse variant, rapid intraperitoneal phagocytosis was induced by vaccination with whole cell bacterial vaccines but not by alpha hemolysin toxoid.
Full Text
The Full Text of this article is available as a PDF (468.5 KB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- COHN Z. A. Determinants of infection in the peritoneal cavity. I. Response to and fate of Staphylococcus aureus and Staphylococcus albus in the mouse. Yale J Biol Med. 1962 Aug;35:12–28. [PMC free article] [PubMed] [Google Scholar]
- Johnson J. E., Cluff L. E., Goshi K. STUDIES ON THE PATHOGENESIS OF STAPHYLOCOCCAL INFECTION : I. THE EFFECT OF REPEATED SKIN INFECTIONS. J Exp Med. 1961 Jan 31;113(2):235–248. doi: 10.1084/jem.113.2.235. [DOI] [PMC free article] [PubMed] [Google Scholar]
- KOENIG M. G. Factors relating to the virulence of staphylococci. I. Comparative studies on two colonial variants. Yale J Biol Med. 1962 Jun;34:537–559. [PMC free article] [PubMed] [Google Scholar]
- KOENIG M. G., MELLY M. A., ROGERS D. E. Factors relating to the virulence of Staphylococci. II. Observations on four mouse-pathogenic strains. J Exp Med. 1962 Nov 1;116:589–599. doi: 10.1084/jem.116.5.589. [DOI] [PMC free article] [PubMed] [Google Scholar]
- KUMAR S., LINDORFER R. K. The characterization of staphylococcal toxins. I. The electrophoretic migration of the alpha hemolytic, dermonecrotic, lethal, and leucocidal activities of crude toxin. J Exp Med. 1962 Jun 1;115:1095–1106. doi: 10.1084/jem.115.6.1095. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kumar S., Loken K. I., Kenyon A. J., Lindorfer R. K. THE CHARACTERIZATION OF STAPHYLOCOCCAL TOXINS : II. THE ISOLATION AND CHARACTERIZATION OF A HOMOGENEOUS STAPHYLOCOCCAL PROTEIN POSSESSING ALPHA HEMOLYTIC, DERMONECROTIC, LETHAL, AND LEUCOCIDAL ACTIVITIES. J Exp Med. 1962 Jun 1;115(6):1107–1115. doi: 10.1084/jem.115.6.1107. [DOI] [PMC free article] [PubMed] [Google Scholar]
- MORSE S. I. Isolation and properties of a surface antigen of Staphylococcus aureus. J Exp Med. 1962 Feb 1;115:295–311. doi: 10.1084/jem.115.2.295. [DOI] [PMC free article] [PubMed] [Google Scholar]
- ROGERS D. E., MELLY M. A. Observations on the immunology of pathogenic staphylococci. Yale J Biol Med. 1962 Jun;34:560–581. [PMC free article] [PubMed] [Google Scholar]
- ROGERS D. E. Staphylococci and man. JAMA. 1962 Jul 7;181:38–40. [PubMed] [Google Scholar]