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The Journal of Experimental Medicine logoLink to The Journal of Experimental Medicine
. 1963 Jul 1;118(1):41–53. doi: 10.1084/jem.118.1.41

COMPARISONS OF BENCE-JONES PROTEINS AND L POLYPEPTIDE CHAINS OF MYELOMA GLOBULINS AFTER HYDROLYSIS WITH TRYPSIN

J H Schwartz 1, G M Edelman 1
PMCID: PMC2137571  PMID: 13987374

Abstract

L polypeptide chains of myeloma globulin and Bence-Jones protein isolated from the same patient were found to be identical after comparison of their tryptic hydrolysates by two-dimensional high voltage electrophoresis. The patterns of peptides from proteins belonging to antigenic group I differed markedly from those of proteins in antigenic group II. A partially purified H chain fraction was compared with L chains from the same myeloma protein. The tryptic hydrolysates yielded dissimilar patterns of peptides. These data indicate that γ-myeloma proteins contain two kinds of polypeptide chains, Hγ chains and either LI or LII chains. The L chains appear to be identical with those comprising the Bence-Jones protein from the same patient.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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