Abstract
The lactic dehydrogenase agent (LDH agent) was found in the urine, feces, and saliva of mice within 24 hours after inoculation. The titer of virus in these materials appears to be directly related to the titer in the plasma. Infection by the oral route occurred only when a high concentration of virus was used. Animals infected prior to mating rarely transmitted the LDH agent to their progeny. However, 91.2 per cent of the progeny of mothers infected during gestation and 51.5 per cent of the progeny of mothers infected within 48 hours after giving birth became infected with the LDH agent. Evidence is discussed which suggests that the transmission of the LDH agent from the infected mother to her offspring is related to the titer of the LDH agent in the maternal circulation.
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Selected References
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- EAGLE H. Amino acid metabolism in mammalian cell cultures. Science. 1959 Aug 21;130(3373):432–437. doi: 10.1126/science.130.3373.432. [DOI] [PubMed] [Google Scholar]
- NOTKINS A. L., GREENFIELD R. E. Infection of tumor-bearing mice with the lactic dehydrogenase agent. Proc Soc Exp Biol Med. 1962 Apr;109:988–991. doi: 10.3181/00379727-109-27400. [DOI] [PubMed] [Google Scholar]
- NOTKINS A. L., GREENFIELD R. E., MARSHALL D., BANE L. Multiple enzyme changes in the plasma of normal and tumor-bearing mice following infection with the lactic dehydrogenase agent. J Exp Med. 1963 Feb 1;117:185–195. doi: 10.1084/jem.117.2.185. [DOI] [PMC free article] [PubMed] [Google Scholar]
- NOTKINS A. L., SHOCHAT S. J. Studies on the multiplication and the properties of the lactic dehydrogenase agent. J Exp Med. 1963 May 1;117:735–747. doi: 10.1084/jem.117.5.735. [DOI] [PMC free article] [PubMed] [Google Scholar]
- PLAGEMANN P. G., WATANABE M., SWIM H. E. Plasma lactic dehydrogenase-elevating agent of mice: effect on levels of additional enzymes. Proc Soc Exp Biol Med. 1962 Dec;111:749–754. doi: 10.3181/00379727-111-27911. [DOI] [PubMed] [Google Scholar]
- RILEY V. Adaptation of orbital bleeding technic to rapid serial blood studies. Proc Soc Exp Biol Med. 1960 Aug-Sep;104:751–754. doi: 10.3181/00379727-104-25975. [DOI] [PubMed] [Google Scholar]
- Riley V., Lilly F., Huerto E., Bardell D. Transmissible Agent Associated with 26 Types of Experimental Mouse Neoplasms. Science. 1960 Aug 26;132(3426):545–547. doi: 10.1126/science.132.3426.545. [DOI] [PubMed] [Google Scholar]
- WROBLEWSKI F., LADUE J. S. Lactic dehydrogenase activity in blood. Proc Soc Exp Biol Med. 1955 Oct;90(1):210–213. doi: 10.3181/00379727-90-21985. [DOI] [PubMed] [Google Scholar]