Abstract
Bence Jones protein injected into rabbits was excreted rapidly into the urine. The excreted protein retained the physicochemical and immunochemical properties of the injected Bence Jones protein. In spite of the rapid excretion, a significant portion of the injected Bence Jones protein was found to be metabolized. After reinjection of radioactive Bence Jones protein into the donor patient, only a little radioactivity was recovered in the urinary protein. The implications of these results are discussed.
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Selected References
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- Bayliss L. E., Kerridge P. M., Russell D. S. The excretion of protein by the mammalian kidney. J Physiol. 1933 Mar 15;77(4):386–398. doi: 10.1113/jphysiol.1933.sp002975. [DOI] [PMC free article] [PubMed] [Google Scholar]
- HARDY S., PUTNAM F. W. Proteins in multiple myeloma. IV. Interaction with metabolic nitrogen. J Biol Chem. 1955 Jan;212(1):371–378. [PubMed] [Google Scholar]
- PUTNAM F. W., HARDY S. Proteins in multiple myeloma. III. Origin of Bence-Jones protein. J Biol Chem. 1955 Jan;212(1):361–369. [PubMed] [Google Scholar]
- PUTNAM F. W., MEYER F., MIYAKE A. Proteins in multiple myeloma. V. Synthesis and excretion of Bence-Jones protein. J Biol Chem. 1956 Jul;221(1):517–528. [PubMed] [Google Scholar]
- PUTNAM F. W., MIYAKE A. Proteins in multiple myeloma. VIII. Biosynthesis of abnormal proteins. J Biol Chem. 1958 Apr;231(2):671–684. [PubMed] [Google Scholar]