Abstract
Pregnant rabbits were sensitized to unrelated does by skin transplantation. The offspring of these sensitized animals rejected skin from the same donor in a markedly accelerated fashion. The transplacental passage of agents responsible for homograft rejection is therefore suggested. Since accelerated rejection rather than enhancement occurred, more than the usual humoral antibodies must have been thus transmitted. The presence of another antibody-like substance is postulated. This appears to be sessile in nature, usually fixed to lymphocytes, but transmissible without these cells under special circumstances, such as occur in micropore chambers or hemochorial placentae. These allow the prolonged dose contact of sensitized and non-sensitized lymphocytes, and thus may permit the transfer of this, usually sessile, but apparently non-fixed antibody.
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Selected References
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- ALGIRE G. H., WEAVER J. M., PREHN R. T. Studies on tissue homotransplantation in mice, using diffusion-chamber methods. Ann N Y Acad Sci. 1957 Mar 22;64(5):1009–1013. doi: 10.1111/j.1749-6632.1957.tb52492.x. [DOI] [PubMed] [Google Scholar]
- BATCHELOR J. R., BOYSE E. A., GORER P. A. Synergic action between isoantibody and immune cells in graft rejection. Transplant Bull. 1960 Oct;26:449–453. doi: 10.1097/00006534-196010000-00037. [DOI] [PubMed] [Google Scholar]
- BERRIAN J. H., BRENT L. Cell-bound antibodies in transplantation immunity. Ann N Y Acad Sci. 1958 Oct 7;73(3):654–662. doi: 10.1111/j.1749-6632.1959.tb40841.x. [DOI] [PubMed] [Google Scholar]
- GORER P. A. Some reactions of H-2 antibodies in vitro and in vivo. Ann N Y Acad Sci. 1958 Oct 7;73(3):707–721. doi: 10.1111/j.1749-6632.1959.tb40848.x. [DOI] [PubMed] [Google Scholar]
- KALISS N. Immunological enhancement of tumor homografts in mice: a review. Cancer Res. 1958 Oct;18(9):992–1003. [PubMed] [Google Scholar]
- KRETSCHMER R. R., PEREZ-TAMAYO R. The role of humoral antibodies in rejection of skin homografts in rabbits. II. Passive transfer of transplantation immunity by sensitized lymph node cells within diffusion chambers. J Exp Med. 1962 Dec 1;116:879–896. doi: 10.1084/jem.116.6.879. [DOI] [PMC free article] [PubMed] [Google Scholar]
- LANMAN J. T., DINERSTEIN J., FIKRIG S. Homograft immunity in pregnancy: lack of harm to the fetus from sensitization of the mother. Ann N Y Acad Sci. 1962 Oct 24;99:706–716. doi: 10.1111/j.1749-6632.1962.tb45355.x. [DOI] [PubMed] [Google Scholar]
- LAWRENCE H. S. Homograft sensitivity. An expression of the immunologic origins and consequences of individuality. Physiol Rev. 1959 Oct;39:811–859. doi: 10.1152/physrev.1959.39.4.811. [DOI] [PubMed] [Google Scholar]
- MANNICK J. A., EGDAHL R. H. Transformation of nonimmune lymph node cells to state of transplantation immunity by RNA. A preliminary report. Ann Surg. 1962 Sep;156:356–366. doi: 10.1097/00000658-196209000-00003. [DOI] [PMC free article] [PubMed] [Google Scholar]
- NAJARIAN J. S., DIXON F. J. Homotransplantation immunity of neonatal rabbits. Proc Soc Exp Biol Med. 1962 Mar;109:592–594. doi: 10.3181/00379727-109-27278. [DOI] [PubMed] [Google Scholar]
- NAJARIAN J. S., FELDMAN J. D. The function of the sensitized lymphocyte in homograft rejection. Ann N Y Acad Sci. 1962 Oct 24;99:470–476. doi: 10.1111/j.1749-6632.1962.tb45328.x. [DOI] [PubMed] [Google Scholar]
- NAJARIAN J. S. Mechanism of homograft rejection. Plast Reconstr Surg Transplant Bull. 1962 Sep;30:359–367. doi: 10.1097/00006534-196209000-00006. [DOI] [PubMed] [Google Scholar]
- SMITH R. T., BRIDGES R. A. Immunological unresponsiveness in rabbits produced by neonatal injection of defined antigens. J Exp Med. 1958 Aug 1;108(2):227–250. doi: 10.1084/jem.108.2.227. [DOI] [PMC free article] [PubMed] [Google Scholar]
- STARK R. B., DWYER E. The enhancement of homografts of skin in the adult rabbit using elements of homologous whole blood. Surgery. 1959 Jul;46(1):277–287. [PubMed] [Google Scholar]
- VALONE J. A. The effect of gestation on experimental skin homografts. Plast Reconstr Surg (1946) 1952 Nov;10(5):354–364. doi: 10.1097/00006534-195211000-00004. [DOI] [PubMed] [Google Scholar]