Skip to main content
The Journal of Experimental Medicine logoLink to The Journal of Experimental Medicine
. 1963 Sep 1;118(3):421–424. doi: 10.1084/jem.118.3.421

THE ATTENUATION OF THE VIRUS OF EPIZOOTIC HEMORRHAGIC DISEASE OF DEER BY ITS SERIAL PASSAGE IN THE BRAINS OF NEWBORN MICE

Richard E Shope 1, Lester G MacNamara 1, Norma E Mettler 1
PMCID: PMC2137652  PMID: 14078001

Abstract

Serial passage through the brains of newborn mice markedly attenuates the New Jersey strain of EHD virus. Deer inoculated with this attenuated virus show no clinical evidence of illness, but do develop virus-neutralizing antibodies in their sera. They also become solidly immune to infection with the regularly fatal unattenuated virus.

Full Text

The Full Text of this article is available as a PDF (213.4 KB).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Shope R. E., Macnamara L. G., Mangold R. A VIRUS-INDUCED EPIZOOTIC HEMORRHAGIC DISEASE OF THE VIRGINIA WHITE-TAILED DEER (ODOCOILEUS VIRGINIANUS). J Exp Med. 1960 Jan 31;111(2):155–170. doi: 10.1084/jem.111.2.155. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from The Journal of Experimental Medicine are provided here courtesy of The Rockefeller University Press

RESOURCES