Abstract
Inbred (C57BL; C3H/Bi), hybrid (C57BL x C3H/Bi), and outbred (TO) mice thymectomized within 24 hours of birth develop wasting symptoms and die prematurely and a proportion of these animals have pathological changes in the liver. The incidence of the liver lesions varies according to the strain of mice used and the lesions tend to occur in animals dying comparatively late. These lesions were shown, by passage of tissue suspensions and of cell-free liver extracts, to be due to a hepatotrophic virus probably mouse hepatitis virus-1 (MHV-1). The part played by the hepatotrophic virus in the premature death of thymectomized mice is discussed but, although neonatal thymectomy apparently alters a normally stable host-virus relationship, it is not thought that the virus is primarily responsible for the death of its host. The role of this virus in the production of the physical wasting is also considered to be problematic.
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Selected References
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- BRAUNSTEINER H., FRIEND C. Viral hepatitis associated with transplantable mouse leukemia. I. Acute hepatic manifestations following treatment with urethane or methylformamide. J Exp Med. 1954 Dec 1;100(6):665–674. doi: 10.1084/jem.100.6.665. [DOI] [PMC free article] [PubMed] [Google Scholar]
- CHEEVER F. S., DANIELS J. B. A murine virus (JHM) causing disseminated encephalomyelitis with extensive destruction of myelin. J Exp Med. 1949 Sep;90(3):181–210. doi: 10.1084/jem.90.3.181. [DOI] [PMC free article] [PubMed] [Google Scholar]
- EAST J., PARROT D. M. Operative techniques for newborn mice using anaesthesia by cooling. J Endocrinol. 1962 Apr;24:249–250. doi: 10.1677/joe.0.0240249. [DOI] [PubMed] [Google Scholar]
- GLEDHILL A. W., ANDREWES C. H., DICK G. W. A. Production of hepatitis in mice by the combined action of two filterable agents. Lancet. 1952 Sep 13;2(6733):509–511. doi: 10.1016/s0140-6736(52)90292-4. [DOI] [PubMed] [Google Scholar]
- GLEDHILL A. W., DICK G. W., NIVEN J. S. Mouse hepatitis virus and its pathogenic action. J Pathol Bacteriol. 1955 Jan-Apr;69(1-2):299–309. doi: 10.1002/path.1700690138. [DOI] [PubMed] [Google Scholar]
- MORRIS J. A. A new member of hepato-encephalitis group of murine viruses. Proc Soc Exp Biol Med. 1959 Apr;100(4):875–877. [PubMed] [Google Scholar]
- NELSON J. B. Acute hepatitis associated with mouse leukemia. I. Pathological features and transmission of the disease. J Exp Med. 1952 May;95(5):293–302. doi: 10.1084/jem.96.4.293. [DOI] [PMC free article] [PubMed] [Google Scholar]
- NIVEN J. S. F., GLEDHILL A. W., DICK G. W. A., ANDREWES C. H. Further light on mouse hepatitis. Lancet. 1952 Nov 29;2(6744):1061–1061. doi: 10.1016/s0140-6736(52)91138-0. [DOI] [PubMed] [Google Scholar]
- PARROTT D. M., EAST J. Role of the thymus in neonatal life. Nature. 1962 Jul 28;195:347–348. doi: 10.1038/195347a0. [DOI] [PubMed] [Google Scholar]
- PARROTT D. M. Strain variation in mortality and runt disease in mice thymectomized at birth. Transplant Bull. 1962 Apr;29:102–104. [PubMed] [Google Scholar]
- ROWE W. P., HARTLEY J. W., CAPPS W. I. Mouse hepatitis virus infection as a highly contagious, prevalent, enteric infection of mice. Proc Soc Exp Biol Med. 1963 Jan;112:161–165. doi: 10.3181/00379727-112-27980. [DOI] [PubMed] [Google Scholar]