Abstract
A simple chamber was constructed for observation of cells at 37°C and under high magnification. Rabbit peritoneal histiocytes observed in this chamber manifested a constant interaction, which lasted as long as the preparation itself. This interaction consisted of formation of cytoplasmic bridges and flow of cytoplasm between the cells. Lung macrophages formed bridges both between themselves, and with peritoneal histiocytes. On the other hand, no bridges were noticed between histiocytes and polymorphonuclears or fibroblasts. BCG bacteria were observed passing from one histiocyte to another. Autoradiographic studies suggest that RNA may be transferred from one cell to another. The possible significance of these observations is discussed.
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Selected References
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- ARONSON M., ELBERG S. Prolifertion of rabbit peritoneal histiocytes as revealed by autoradiography with tritiated thymidine. Proc Natl Acad Sci U S A. 1962 Feb;48:208–214. doi: 10.1073/pnas.48.2.208. [DOI] [PMC free article] [PubMed] [Google Scholar]
- ELBERG S. S., FONG J., SCHNEIDER P. Studies on tubercle bacillus-monocyte relationship. I. Quantitative analysis of effect of serum of animals vaccinated with BCG upon bacterium-monocyte system. J Exp Med. 1956 Oct 1;104(4):455–465. doi: 10.1084/jem.104.4.455. [DOI] [PMC free article] [PubMed] [Google Scholar]
- FISHMAN M. Antibody formation in vitro. J Exp Med. 1961 Dec 1;114:837–856. doi: 10.1084/jem.114.6.837. [DOI] [PMC free article] [PubMed] [Google Scholar]
- MYRVIK Q. N., LEAKE E. S., FARISS B. Lysozyme content of alveolar and peritoneal macrophages from the rabbit. J Immunol. 1961 Feb;86:133–136. [PubMed] [Google Scholar]