Abstract
Isotopic labeling of plasma proteins in vitro by tissues from staphylococcal-infected and control mice was examined, using autoradiography of immunoelectrophoretic patterns. The results indicate that in infected animals there is hyperactivity of liver tissue in producing albumin, α- and β-globulins, and of spleen tissue in producing immune globulins. The observed increase in labeling of some proteins by tissues from infected mice is to a large extent correlated with an increase of these proteins in the serum.
Full Text
The Full Text of this article is available as a PDF (725.5 KB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Asofsky R., Thorbecke G. J. SITES OF FORMATION OF IMMUNE GLOBULINS AND OF A COMPONENT OF C'(3): II. PRODUCTION OF IMMUNOELECTROPHORETICALLY IDENTIFIED SERUM PROTEINS BY HUMAN AND MONKEY TISSUES IN VITRO. J Exp Med. 1961 Sep 30;114(4):471–483. doi: 10.1084/jem.114.4.471. [DOI] [PMC free article] [PubMed] [Google Scholar]
- DURRUM E. L., JENCKS W. P., SMITH E. R. The clinical significance of the analysis of serum protein distribution by filter paper electrophoresis. Am J Med. 1956 Sep;21(3):387–405. doi: 10.1016/0002-9343(56)90039-0. [DOI] [PubMed] [Google Scholar]
- EAGLE H., OYAMA V. I., LEVY M., HORTON C. L., FLEISCHMAN R. The growth response of mammalian cells in tissue culture to L-glutamine and L-glutamic acid. J Biol Chem. 1956 Feb;218(2):607–616. [PubMed] [Google Scholar]
- GRAHAM R. G., DOBSON H. L., YOW E. M. Serum protein fraction response in infection. Am J Med Sci. 1958 Jun;235(6):682–688. doi: 10.1097/00000441-195806000-00011. [DOI] [PubMed] [Google Scholar]
- HEISKELL C. L., CARPENTER C. M., WEIMER H. E., NAKAGAWA S. Serum glycoproeins in infectious and inflammatory diseases. Ann N Y Acad Sci. 1961 Aug 31;94:183–209. doi: 10.1111/j.1749-6632.1961.tb35541.x. [DOI] [PubMed] [Google Scholar]
- Hochwald G. M., Thorbecke G. J., Asofsky R. SITES OF FORMATION OF IMMUNE GLOBULINS AND OF A COMPONENT OF C'(3): I. A NEW TECHNIQUE FOR THE DEMONSTRATION OF THE SYNTHESIS OF INDIVIDUAL SERUM PROTEINS BY TISSUES IN VITRO. J Exp Med. 1961 Sep 30;114(4):459–470. doi: 10.1084/jem.114.4.459. [DOI] [PMC free article] [PubMed] [Google Scholar]
- NEUMAN R. E., McCOY T. A. Growth-promoting properties of pyruvate oxal-acetate, and alpha-ketoglutarate for isolated Walker carcinosarcoma 256 cells. Proc Soc Exp Biol Med. 1958 Jun;98(2):303–306. doi: 10.3181/00379727-98-24025. [DOI] [PubMed] [Google Scholar]
- RICE E. W. A study on correlation between C-reactive protein and certain other acute-phase reactants. Clin Chim Acta. 1961 Mar;6:170–173. doi: 10.1016/0009-8981(61)90081-x. [DOI] [PubMed] [Google Scholar]
- SCHAEDLER R. W., DUBOS R. J. The fecal flora of various strains of mice. Its bearing on their susceptibility to endotoxin. J Exp Med. 1962 Jun 1;115:1149–1160. doi: 10.1084/jem.115.6.1149. [DOI] [PMC free article] [PubMed] [Google Scholar]
- WILLIAMS C. A., Jr, WEMYSS C. T., Jr Changes produced in mouse plasma proteins by acute bacterial infections. J Exp Med. 1961 Sep 1;114:311–325. doi: 10.1084/jem.114.3.311. [DOI] [PMC free article] [PubMed] [Google Scholar]