Abstract
An experimental model has been developed for the reproducible transmission of influenza virus infection from experimentally infected mice to uninfected cage mates. Infector mice transmit influenza virus infection most readily during the period 24 to 48 hours after initiation of their infection. This restricted period of transmission is not due to declining titers of infective virus in the nose, trachea, or lungs of infector mice after 48 hours of infection, since peak titers in these tissues are maintained for another 48 hours. A mouse-adapted strain of A2 virus was found to be more readily transmitted than the mouse-adapted CAM strain of influenza A1 virus, although the CAM strain induced higher pulmonary virus titers and more extensive lung lesions.
Full Text
The Full Text of this article is available as a PDF (518.9 KB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Eaton M. D. Transmission of Epidemic Influenza Virus in Mice by Contact. J Bacteriol. 1940 Mar;39(3):229–241. doi: 10.1128/jb.39.3.229-241.1940. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Francis T., Jr TRANSMISSION OF INFLUENZA BY A FILTERABLE VIRUS. Science. 1934 Nov 16;80(2081):457–459. doi: 10.1126/science.80.2081.457-a. [DOI] [PubMed] [Google Scholar]
- IIDA T., BANG F. B. Infection of the upper respiratory tract of mice with influenza A virus. Am J Hyg. 1963 Mar;77:169–176. doi: 10.1093/oxfordjournals.aje.a120306. [DOI] [PubMed] [Google Scholar]
- LOOSLI C. G. The pathogenesis and pathology of experimental air-borne influenza virus A infections in mice. J Infect Dis. 1949 MarâApr;84(2):153–168. doi: 10.1093/infdis/84.2.153. [DOI] [PubMed] [Google Scholar]
- SCHULMAN J. L., KILBOURNE E. D. Airborne transmission of influenza virus infection in mice. Nature. 1962 Sep 15;195:1129–1130. doi: 10.1038/1951129a0. [DOI] [PubMed] [Google Scholar]