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. 1964 Oct 1;120(4):611–628. doi: 10.1084/jem.120.4.611

IMMUNOLOGICAL AND BIOCHEMICAL STUDIES ON SERUM HAPTOGLOBIN

Bong-Sop Shim 1, Alexander G Bearn 1
PMCID: PMC2137779  PMID: 14212123

Abstract

Antibody to purified type 1-1 human serum haptoglobin was obtained in rabbits. Using this antiserum it was demonstrated that the antigenic determinants of the haptoglobin molecule reside in both α- and β-chains. No immunological difference between the normal α1F- and α1S-chains of haptoglobin could be detected. A number of healthy individuals whose haptoglobin pattern appeared normal by starch gel electrophoresis were shown to possess a haptoglobin which could be distinguished immunologically from the common haptoglobin types. These immunological atypical haptoglobins have been observed in individuals of types 1-1, 2-1, and 2-2. Combined immunological and chemical studies of purified haptoglobin have enabled the construction of a tentative model for the structure of human type 1-1 haptoglobin.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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