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. 1964 Nov 30;120(6):1169–1188.

ON THE RELATIONSHIPS BETWEEN THE γ-GLOBULIN GENES OF THE GM SYSTEM

A STUDY OF GM GENE PRODUCTS IN SERA, MYELOMA GLOBULINS, AND SPECIFIC ANTIBODIES WITH SPECIAL REFERENCE TO THE GENE GMf

Lars Mårtensson 1
PMCID: PMC2137797  PMID: 14238933

Abstract

Gm types of sera from Caucasians and Negroes, of myeloma globulins, and of specific antibodies were investigated. In particular the relationship between the recently identified gene Gmf and other Gm genes was analyzed. 1. Caucasians were, with rare exceptions, either Gm(b+f+) or Gm(b-f-). 2. In Negroes, on the other band, type Gm(b+f-) was found to be common. 3. No myeloma globulins appeared to contain the product of more than 1 of the 3 genes Gma, Gmb, and Gmf, even though the large majority of normal individuals, as well as myeloma patients, possess 2 or all 3 of these genes. 4. The types Gm(a+b-f-) and Gm(a-b-f+) represented the 2 major groups among the γ2-myeloma globulins; each comprised roughly 40 per cent. The types Gm(a- b+f-) and Gm(a-b-f-) are minor groups. 5. All Gm(x+) myeloma globulins were also Gm(a+). Approximately half of the Gm(a+) myeloma globulins were Gm(x+). 6. In the majority, but not in all, of Gm(a+) sera the anti-Rh antibodies were clearly Gm(a+). Similarly, the anti-Rh antibodies of Gm(f+) sera were most often, but not always, also Gm(f+). In contrast, only a minor proportion of Gm(b+) anti-Rh sera sensitized red cells to anti-Gm(b).

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Selected References

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  1. ALLLEN J. C., KUNKEL H. G., KABAT E. A. STUDIES ON HUMAN ANTIBODIES. II. DISTRIBUTION OF GENETIC FACTORS. J Exp Med. 1964 Mar 1;119:453–465. doi: 10.1084/jem.119.3.453. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. COHEN S. Properties of the separated chains of human gamma-globulin. Nature. 1963 Jan 19;197:253–255. doi: 10.1038/197253a0. [DOI] [PubMed] [Google Scholar]
  3. COLBERG J. E., DRAY S. LOCALIZATION BY IMMUNOFLUORESCENCE OF GAMMA-GLOBULIN ALLOTYPES IN LYMPH NODE CELLS OF HOMOZYGOUS AND HETEROZYGOUS RABBITS. Immunology. 1964 May;7:273–290. [PMC free article] [PubMed] [Google Scholar]
  4. FRANKLIN E. C., FUDENBERG H., MELTZER M., STANWORTH D. R. The structural basis for genetic variations of normal human gamma-globulins. Proc Natl Acad Sci U S A. 1962 Jun 15;48:914–922. doi: 10.1073/pnas.48.6.914. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. FUDENBERG H. The hereditary human gamma globulin (Gm) groups: interpretations and extensions. Prog Allergy. 1963;7:1–31. [PubMed] [Google Scholar]
  6. GLASS B., LI C. C. The dynamics of racial intermixture; an analysis based on the American Negro. Am J Hum Genet. 1953 Mar;5(1):1–20. [PMC free article] [PubMed] [Google Scholar]
  7. GREY H. M., KUNKEL H. G. H CHAIN SUBGROUPS OF MYELOMA PROTEINS AND NORMAL 7S GAMMA-GLOBULIN. J Exp Med. 1964 Aug 1;120:253–266. doi: 10.1084/jem.120.2.253. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. HARBOE M., LUNDEVALL J. A new type in the Gm system. Acta Pathol Microbiol Scand. 1959;45(4):357–370. doi: 10.1111/j.1699-0463.1959.tb04721.x. [DOI] [PubMed] [Google Scholar]
  9. HARBOE M., OSTERLAND C. K., KUNKEL H. G. Localization of two genetic factors to different areas of gamma-globulin molecules. Science. 1962 Jun 15;136(3520):979–980. doi: 10.1126/science.136.3520.979. [DOI] [PubMed] [Google Scholar]
  10. HARBOE M., OSTERLAND C. K., MANNIK M., KUNKEL H. G. Genetic characters of human gamma-globulins in myeloma proteins. J Exp Med. 1962 Nov 1;116:719–738. doi: 10.1084/jem.116.5.719. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. KUNKEL H. G., ALLEN J. C., GREY H. M., MARTENSSON L., GRUBB R. A RELATIONSHIP BETWEEN THE H CHAIN GROUPS OF 7S GAMMA-GLOBULIN AND THE GM SYSTEM. Nature. 1964 Jul 25;203:413–414. doi: 10.1038/203413a0. [DOI] [PubMed] [Google Scholar]
  12. NILSSON U. GM CHARACTERS OF 7 S GAMMA-MYELOMA PROTEINS AND CORRESPONDING INDIVIDUAL NORMAL GAMMA-GLOBULINS. Acta Pathol Microbiol Scand. 1964;61:181–189. doi: 10.1111/apm.1964.61.2.181. [DOI] [PubMed] [Google Scholar]
  13. OSSERMAN E. F., TAKATSUKI K. PLASMA CELL MYELOMA: GAMMA GLOBULIN SYNTHESIS AND STRUCTURE. A REVIEW OF BIOCHEMICAL AND CLINICAL DATA, WITH THE DESCRIPTION OF A NEWLY-RECOGNIZED AND RELATED SYNDROME, "H-GAMMA-2-CHAIN (FRANKLIN'S) DISEASE. Medicine (Baltimore) 1963 Nov;42:357–384. [PubMed] [Google Scholar]
  14. RIEDER R. F., OUDIN J. STUDIES ON THE RELATIONSHIP OF ALLOTYPIC SPECIFICITIES TO ANTIBODY SPECIFICITIES IN THE RABBIT. J Exp Med. 1963 Oct 1;118:627–633. doi: 10.1084/jem.118.4.627. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. RITTER H., ROPARTZ C., ROUSSEAU P. Y., RIVAT L., SATI A. STUDIES ON THE FORMAL GENETICS OF THE GAMMAGLOBULIN POLYMORPHISM GM (CHARACTERS GM(B), GM(X)); A STUDY OF 386 FAMILIES. Vox Sang. 1964 May-Jun;9:340–348. doi: 10.1111/j.1423-0410.1964.tb02622.x. [DOI] [PubMed] [Google Scholar]

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