Abstract
As determined by serial histologic study, the leukocyte component of the acute inflammatory response to thermal injury in the medulla of the kidney of rabbits was markedly delayed and diminished in intensity when compared with the response of the cortex. Similar differences in granulocyte mobilization between cortex and medulla were seen following the inoculation of bacteria. Hydronephrosis produced by ureteral ligation had no discernible effect upon the inflammatory response in either cortex or medulla following thermal burns. The susceptibility of the cortex to E. coli infection was markedly enhanced during leukopenia induced by nitrogen-mustard. These results suggest that deficiencies in granulocyte mobilization play an important role in the increased susceptibility of the renal medulla to bacterial infection.
Full Text
The Full Text of this article is available as a PDF (1,015.1 KB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- BEESON P. B., ROWLEY D. The anticomplementary effect of kidney tissue; its association with ammonia production. J Exp Med. 1959 Nov 1;110:685–697. doi: 10.1084/jem.110.5.685. [DOI] [PMC free article] [PubMed] [Google Scholar]
- CHERNEW I., BRAUDE A. I. Depression of phagocytosis by solutes in concentrations found in the kidney and urine. J Clin Invest. 1962 Oct;41:1945–1953. doi: 10.1172/JCI104652. [DOI] [PMC free article] [PubMed] [Google Scholar]
- FREEDMAN L. R., BEESON P. B. Experimental pyelonephritis. IV. Observations on infections resulting from direct inoculation of bacteria in different zones of the kidney. Yale J Biol Med. 1958 Jun;30(6):406–414. [PMC free article] [PubMed] [Google Scholar]
- HURLEY J. V., SPECTOR W. G. Delayed leucocytic emigration after intra-dermal injections and thermal injury. J Pathol Bacteriol. 1961 Oct;82:421–429. doi: 10.1002/path.1700820219. [DOI] [PubMed] [Google Scholar]
- LEONHARDT K. O., LANDES R. R. Oxygen tension of the urine and renal structures. Preliminary report of clinical findings. N Engl J Med. 1963 Jul 18;269:115–121. doi: 10.1056/NEJM196307182690301. [DOI] [PubMed] [Google Scholar]
- MILES A. A., MILES E. M., BURKE J. The value and duration of defence reactions of the skin to the primary lodgement of bacteria. Br J Exp Pathol. 1957 Feb;38(1):79–96. [PMC free article] [PubMed] [Google Scholar]
- PAPPENHEIMER J. R., KINTER W. B. Hematocrit ratio of blood within mammalian kidney and its significance for renal hemodynamics. Am J Physiol. 1956 May;185(2):377–390. doi: 10.1152/ajplegacy.1956.185.2.377. [DOI] [PubMed] [Google Scholar]
- PERILLIE P. E., FINCH S. C. The local exudative cellular response in leukemia. J Clin Invest. 1960 Sep;39:1353–1357. doi: 10.1172/JCI104153. [DOI] [PMC free article] [PubMed] [Google Scholar]
- ROCHA H., GUZE L. B., FREEDMAN L. R., BEESON P. B. Experimental pyelonephritis. III. The influence of localized injury in different parts of the kidney on susceptibility to bacillary infection. Yale J Biol Med. 1958 Apr;30(5):341–354. [PMC free article] [PubMed] [Google Scholar]
- SANFORD J. P., HUNTER B. W., DONALDSON P. Localization and fate of Escherichia coli in hematogenous pyelonephritis. J Exp Med. 1962 Sep 1;116:285–294. doi: 10.1084/jem.116.3.285. [DOI] [PMC free article] [PubMed] [Google Scholar]
- SHELDON W. H., BAUER H. The development of the acute inflammatory response to experimental cutaneous mucormycosis in normal and diabetic rabbits. J Exp Med. 1959 Dec 1;110:845–852. doi: 10.1084/jem.110.6.845. [DOI] [PMC free article] [PubMed] [Google Scholar]