Abstract
Hemophilus pleuropneumoniae is highly pathogenic for swine when given intranasally. As few as 100 organisms induce characteristic porcine contagious pleuropneumonia (PCP) and, when as many as one-half million are given, the infection usually proceeds to a fatal termination. While the organism is highly pathogenic when introduced by way of the respiratory tract, it is innocuous when given subcutaneously even in large numbers. Swine that have been inoculated subcutaneously are rendered solidly immune to infection with H. pleuropneumoniae intranasally. The marked pathogenicity of H. pleuropneumoniae for swine has been contrasted with the lack of pathogenicity of another swine Hemophilus, H. influenzae suis. It has been pointed out that, in its high degree of pathogenicity, in its pneumotropism, and in its immunogenicity by a non-respiratory route of inoculation, H. pleuropneumoniae appears to resemble certain viruses more than it does a bacterium.
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Selected References
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- LEIDY G., JAFFEE I., ALEXANDER H. E. Emergence of competence (for transformation) of three Hemophilus species in a chemically defined environment. Proc Soc Exp Biol Med. 1962 Dec;111:725–731. doi: 10.3181/00379727-111-27904. [DOI] [PubMed] [Google Scholar]
- Lewis P. A., Shope R. E. SWINE INFLUENZA : II. A HEMOPHILIC BACILLUS FROM THE RESPIRATORY TRACT OF INFECTED SWINE. J Exp Med. 1931 Jul 31;54(3):361–371. doi: 10.1084/jem.54.3.361. [DOI] [PMC free article] [PubMed] [Google Scholar]
- SHOPE R. E. PORCINE CONTAGIOUS PLEUROPNEUMONIA. I. EXPERIMENTAL TRANSMISSION, ETIOLOGY, AND PATHOLOGY. J Exp Med. 1964 Mar 1;119:357–368. doi: 10.1084/jem.119.3.357. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Shope R. E. IMMUNIZATION OF RABBITS TO INFECTIOUS PAPILLOMATOSIS. J Exp Med. 1937 Jan 31;65(2):219–231. doi: 10.1084/jem.65.2.219. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Shope R. E. STUDIES ON IMMUNITY TO SWINE INFLUENZA. J Exp Med. 1932 Sep 30;56(4):575–585. doi: 10.1084/jem.56.4.575. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Shope R. E. SWINE INFLUENZA : III. FILTRATION EXPERIMENTS AND ETIOLOGY. J Exp Med. 1931 Jul 31;54(3):373–385. doi: 10.1084/jem.54.3.373. [DOI] [PMC free article] [PubMed] [Google Scholar]
- WHITE D. C., SMITH L. Hematin enzymes of Hemophilus parainfluenzae. J Biol Chem. 1962 Apr;237:1332–1336. [PubMed] [Google Scholar]