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. 1964 Feb 29;119(3):453–465. doi: 10.1084/jem.119.3.453

STUDIES ON HUMAN ANTIBODIES

II. DISTRIBUTION OF GENETIC FACTORS

James C Allen 1, Henry G Kunkel 1, Elvin A Kabat 1
PMCID: PMC2137883  PMID: 14129716

Abstract

Human antibodies against dextran, teichoic acid, blood group A substance, levan, tetanus toxoid, and nuclei were isolated and analyzed for their content of Gm(a), Gm(b), and Inv(a) γ-globulin genetic factors. The majority of these antibodies contained all the genetic factors determined in the donor's whole γ-globulin, but in many antibodies at very different concentrations. In a few instances specific factors could not be detected despite their presence in the individual's whole γ-globulin. Different antibodies isolated from the serum of the same individual showed different relative concentrations of genetic factors. The distribution of genetic factors seen in certain isolated human antibodies appeared to approach the selective occurrence of these factors in myeloma proteins.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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