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. 1965 Feb 28;121(3):395–401. doi: 10.1084/jem.121.3.395

THE BRAIN LESION OF GOLDTHIOGLUCOSE OBESITY

G Brecher 1, G L Laqueur 1, E P Cronkite 1, P M Edelman 1, I L Schwartz 1
PMCID: PMC2137955  PMID: 14270240

Abstract

The development of hypothalamic lesions due to goldthioglucose are described. The initial extensive necrotic lesion occurs in close to 100 per cent of animals injected with LD 50. Within 2 weeks the necrotic material has been removed and a narrow scar results. After a lapse of several months, the scar is often difficult to visualize, especially in animals that have not developed obesity. The ventromedial nucleus is not the center of the lesion. The nucleus is preserved in some instances, and partially or completely destroyed in others, depending on the extent of the lesion. The more prominent scar in the obese animals correlates with the larger initial lesion necessary for the complete bilateral destruction of the ventromedial nucleus which is known to be a prerequisite for the development of hypothalamic obesity. Thus, contrary to earlier suggestions, goldthioglucose does not localize specifically in the cells of the ventromedial nucleus.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BRECHER G., WAXLER S. H. Obesity in albino mice due to single injections of goldthioglucose. Proc Soc Exp Biol Med. 1949 Mar;70(3):498–501. doi: 10.3181/00379727-70-16971. [DOI] [PubMed] [Google Scholar]
  2. COGGESHALL R. E., MACLEAN P. D. Cerebral effects of 3-acetylpyridine in the squirrel monkey (Saimiri sciureus). Trans Am Neurol Assoc. 1959;84:169–170. [PubMed] [Google Scholar]
  3. COGGESHALL R. E., MACLEAN P. D. Hippocampal lesions following administration of 3-acetylpyridine. Proc Soc Exp Biol Med. 1958 Aug-Sep;98(4):687–689. doi: 10.3181/00379727-98-24152. [DOI] [PubMed] [Google Scholar]
  4. DEBONS A. F., SILVER L., CRONKITE E. P., JOHNSON H. A., BRECHER G., TENZER D., SCHWARTZ I. L. Localization of gold in mouse brain in relation to gold thioglucose obesity. Am J Physiol. 1962 Apr;202:743–750. doi: 10.1152/ajplegacy.1962.202.4.743. [DOI] [PubMed] [Google Scholar]
  5. HIGHMAN B., MALING H. M. Neuropathologic lesions in dogs after prolonged administration of phenylisopropylhydrazine (JB 516) and phenylisobutylhydrazine (JB 835). J Pharmacol Exp Ther. 1962 Sep;137:344–355. [PubMed] [Google Scholar]
  6. LIEBELT R. A., SEKIBA K., LIEBELT A. G., PERRY J. H. Genetic susceptibility to goldthioglucose-induced obesity in mice. Proc Soc Exp Biol Med. 1960 Aug-Sep;104:689–692. doi: 10.3181/00379727-104-25953. [DOI] [PubMed] [Google Scholar]
  7. MARSHALL N. B., BARRNETT R. J., MAYER J. Hypothalamic lesions in goldthioglucose injected mice. Proc Soc Exp Biol Med. 1955 Oct;90(1):240–244. doi: 10.3181/00379727-90-21995. [DOI] [PubMed] [Google Scholar]
  8. MARSHALL N. B., MAYER J. Specificity of gold thioglucose for ventromedial hypothalamic lesions and hyperphagia. Nature. 1956 Dec 22;178(4547):1399–1400. doi: 10.1038/1781399a0. [DOI] [PubMed] [Google Scholar]
  9. MAYER J., FRENCH R. G., ZIGHERA C. F., BARRNETT R. J. Hypothalamic obesity in the mouse: production, description and metabolic characteristics. Am J Physiol. 1955 Jul;182(1):75–82. doi: 10.1152/ajplegacy.1955.182.1.75. [DOI] [PubMed] [Google Scholar]
  10. MAYER J. Some advances in the study of the physiologic basis of obesity. Metabolism. 1957 Sep;6(5):435–446. [PubMed] [Google Scholar]
  11. MORGANE P. J. Alterations in feeding and drinking behavior of rats with lesions in globi pallidi. Am J Physiol. 1961 Sep;201:420–428. doi: 10.1152/ajplegacy.1961.201.3.420. [DOI] [PubMed] [Google Scholar]
  12. MORGANE P. J. Electrophysiological studies of feeding and satiety centers in the rat. Am J Physiol. 1961 Nov;201:838–844. doi: 10.1152/ajplegacy.1961.201.5.838. [DOI] [PubMed] [Google Scholar]
  13. PERRY J. H., LIEBELT R. A. Extra-hypothalamic lesions associated with gold-thioglucose induced obesity. Proc Soc Exp Biol Med. 1961 Jan;106:55–57. doi: 10.3181/00379727-106-26236. [DOI] [PubMed] [Google Scholar]
  14. SCHWARTZ I. L., CRONKITE E. P., JOHNSON H. A., SILVER L., TENZER D., DEBONS A. F. Radioautographic localization of the "satiety center". Trans Assoc Am Physicians. 1961;74:300–317. [PubMed] [Google Scholar]

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