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. 1965 Jan 31;121(2):235–246. doi: 10.1084/jem.121.2.235

PLATELETS AND THE SHWARTZMAN PHENOMENON

Jack Levin 1, Leighton E Cluff 1
PMCID: PMC2137980  PMID: 14264269

Abstract

Studies are reported on the effect of immunologically induced thrombocytopenia upon the local and generalized Shwartzman phenomena. Intravenous injection of antiplatelet serum to rabbits produced profound but transient thrombocytopenia unaccompanied by significant changes in circulating leucocytes. Platelet antiserum alone given to rabbits prepared with thorotrast produced renal lesions characteristic of the Shwartzman reaction. Thrombocytopenia induced by platelet antiserum did not inhibit the cutaneous hemorrhagic lesion of the local Shwartzman phenomenon produced by sequential injections of endotoxin intracutaneously and intravenously. The implications of these observations in the pathogenesis of the local cutaneous and generalized Shwartzman reaction are discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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