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. 1965 Jun 1;121(6):889–900. doi: 10.1084/jem.121.6.889

METABOLISM AND FUNCTION OF GAMMA GLOBULIN IN ALEUTIAN DISEASE OF MINK

David D Porter 1, Frank J Dixon 1, Austin E Larsen 1
PMCID: PMC2138022  PMID: 14319405

Abstract

Aleutian disease-affected mink, which are markedly hypergammaglobulinemic, show a decreased half-life of the serum gamma globulin indicating that the hyperglobulinemia is due to increased production. No evidence that the gamma globulin was antibody to the infectious agent, to autologous or isologous tissues, or to antigens the animal was responding to prior to development of the disease was obtained. The increased gamma globulin was found to be of the 6.4S variety, and gamma globulin containing protein-protein complexes of 9S to 17S and 22S to 25S classes were observed in serums of affected mink. The findings are most consistent with the Aleutian disease virus acting as a direct and somewhat selective stimulus to plasma cell proliferation. There is no evidence that the arterial and glomerular lesions of Aleutian disease have an immunologic pathogenesis. It seems possible that these vascular changes may be directly caused by the viral agent, or may be the result of the increased gamma globulin levels.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ANDERSEN S. B., BJORNEBOE M. GAMMA GLOBULIN TURNOVER IN RABBITS BEFORE AND DURING HYPERIMMUNIZATION. J Exp Med. 1964 Apr 1;119:537–546. doi: 10.1084/jem.119.4.537. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. DIXON F. J., FELDMAN J. D., VAZQUEZ J. J. Experimental glomerulonephritis. The pathogenesis of a laboratory model resembling the spectrum of human glomerulonephritis. J Exp Med. 1961 May 1;113:899–920. doi: 10.1084/jem.113.5.899. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. DIXON F. J., VAZQUEZ J. J. Immunohistochemical analysis of amyloid by the fluorescence technique. J Exp Med. 1956 Nov 1;104(5):727–736. doi: 10.1084/jem.104.5.727. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. FISHER E. R., PEREZ-STABLE E., ZAWADZKI Z. A. ULTRASTRUCTURAL RENAL CHANGES IN MULTIPLE MYELOMA WITH COMMENTS RELATIVE TO THE MECHANISM OF PROTEINURIA. Lab Invest. 1964 Dec;13:1561–1574. [PubMed] [Google Scholar]
  5. HELMBOLDT C. F., JUNGHERR E. L. The pathology of Aleutian disease in mink. Am J Vet Res. 1958 Jan;19(70):212–222. [PubMed] [Google Scholar]
  6. HENSON J. B., GORHAM J. R., LEADER R. W., WAGNER B. M. Experimental hypergammaglobulinemia in mink. J Exp Med. 1962 Sep 1;116:357–364. doi: 10.1084/jem.116.3.357. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. KENYON A. J., TRAUTWEIN G., HELMBOLDT C. F. Characterization of blood serum proteins from mink with Aleutian disease. Am J Vet Res. 1963 Jan;24:168–173. [PubMed] [Google Scholar]
  8. KUNKEL H. G., MULLER-EBERHARD H. J., FUDENBERG H. H., TOMASI T. B. Gamma globulin complexes in rheumatoid arthritis and certain other conditions. J Clin Invest. 1961 Jan;40:117–129. doi: 10.1172/JCI104224. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. LEADER R. W. LOWER ANIMALS, SPONTANEOUS DISEASE, AND MAN. Arch Pathol. 1964 Oct;78:390–404. [PubMed] [Google Scholar]
  10. LEADER R. W., WAGNER B. M., HENSON J. B., GORHAM J. R. Structural and histochemical observations of liver and kidney in Aleutian disease of mink. Am J Pathol. 1963 Jul;43:33–53. [PMC free article] [PubMed] [Google Scholar]
  11. MCDEVITT H. O., PETERS J. H., POLLARD L. W., HARTER J. G., COONS A. H. PURIFICATION AND ANALYSIS OF FLUORESCEIN-LABELED ANTISERA BY COLUMN CHROMATOGRAPHY. J Immunol. 1963 Apr;90:634–642. [PubMed] [Google Scholar]
  12. OSLER A. G., STRAUSS J. H., MAYER M. M. Diagnostic complement fixation. I. A method. Am J Syph Gonorrhea Vener Dis. 1952 Mar;36(2):140–153. [PubMed] [Google Scholar]
  13. PORTER D. D., LARSEN A. E. STATISTICAL SURVEY OF ALEUTIAN DISEASE IN RANCH MINK. Am J Vet Res. 1964 Jul;25:1226–1229. [PubMed] [Google Scholar]
  14. ROTHSCHILD M. A., ORATZM, FRANKLINEC, SCHREIBER S. S. The effect of hypergammaglobulinemia on albumin metabolism in hyperimmunized rabbits studied with albumin-I-131. J Clin Invest. 1962 Jul;41:1564–1571. doi: 10.1172/JCI104613. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. SOLOMON A., WALDMANN T. A., FAHEY J. L. Clinical and experimental metabolism of normal 6.6s gamma-globulin in normal subjects and in patients with macroglobulinemia and multiple myeloma. J Lab Clin Med. 1963 Jul;62:1–17. [PubMed] [Google Scholar]
  16. TALMAGE D. W., MAURER P. H. I131-Labelled antigen precipitation as a measure of quantity and quality of antibody. J Infect Dis. 1953 May-Jun;92(3):288–300. doi: 10.1093/infdis/92.3.288. [DOI] [PubMed] [Google Scholar]
  17. THOMPSON G. R., ALIFERIS P. A CLINICAL-PATHOLOGICAL STUDY OF ALEUTIAN MINK DISEASE; AN EXPERIMENTAL MODEL FOR STUDY OF THE CONNECTIVE-TISSUE DISEASES. Arthritis Rheum. 1964 Oct;7:521–533. doi: 10.1002/art.1780070508. [DOI] [PubMed] [Google Scholar]
  18. UNANUE E., DIXON F. J. EXPERIMENTAL GLOMERULONEPHRITIS. IV. PARTICIPATION OF COMPLEMENT IN NEPHROTOXIC NEPHRITIS. J Exp Med. 1964 Jan 1;119:965–982. doi: 10.1084/jem.119.6.965. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. WAGNER B. M. ALEUTIAN DISEASE OF MINK. Arthritis Rheum. 1963 Aug;6:386–389. doi: 10.1002/art.1780060411. [DOI] [PubMed] [Google Scholar]
  20. WEIGLE W. O., DIXON F. J. Relationship of circulating antigen-antibody complexes, antigen elimination, and complement fixation in serum sickness. Proc Soc Exp Biol Med. 1958 Oct;99(1):226–231. doi: 10.3181/00379727-99-24304. [DOI] [PubMed] [Google Scholar]

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